PMID: 59153Jul 10, 1976

Peptide transmitters: a unifying hypothesis for euphoria, respiration, sleep, and the action of lithium

Lancet
R Byck

Abstract

Actions of morphine include analgesia, sleep, euphoria, and depression of respiration. Transmitter or modulator substances in the brain that have actions similar to morphine may control these functions in man. This hypothesis proposes that enkephalin is a controlling neurotransmitter and its binding to opiate receptors determines mood state as well as influencing respiratory and sleep patterns. Lithium may act through modification of the opiate receptor affinity for an endogenous morphine-like substance. The theory predicts blocking action of naloxone in mania and in most drug-induced euphorias. It implies a new chemical pathophysiological basis for the phenomenology of mental illness.

Citations

Aug 15, 1992·Biological Psychiatry·A F Martín del CampoA Grossman
Jun 15, 1979·Brain Research·G SterbaF Schober
Dec 1, 1981·Physiology & Behavior·C M ContrerasR Palmour
Nov 1, 1978·Pharmacology, Biochemistry, and Behavior·N K Mello, J H Mendelson
Sep 3, 1981·The New England Journal of Medicine·O Appenzeller
Jan 1, 1978·Annals of the New York Academy of Sciences·H D Kleber, M S Gold
Jan 1, 1977·Journal of the American Academy of Child Psychiatry·D J Cohen, J G Young
Apr 7, 1977·Nature·J D Belluzzi, L Stein
Jan 1, 1982·Annals of the New York Academy of Sciences·J VolavkaG Koz
Jan 1, 1982·Annals of the New York Academy of Sciences·D PickarW E Bunney
Jun 30, 2015·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·O A GromovaO P Alexandrova
Jul 1, 1984·Drug Intelligence & Clinical Pharmacy·M W JannS R Saklad
Jan 1, 1982·Annals of the New York Academy of Sciences·D H CatlinR H Gerner

Related Concepts

Brain
Euphoric Mood
Lithium
Parasympathetic Nervous System
Polypeptides
Receptors, Drug
Respiration
Sleep, Slow-Wave
Neurohormones

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