Peptide Vaccine: Progress and Challenges

Vaccines
Weidang LiAshlesh K Murthy

Abstract

Conventional vaccine strategies have been highly efficacious for several decades in reducing mortality and morbidity due to infectious diseases. The bane of conventional vaccines, such as those that include whole organisms or large proteins, appear to be the inclusion of unnecessary antigenic load that, not only contributes little to the protective immune response, but complicates the situation by inducing allergenic and/or reactogenic responses. Peptide vaccines are an attractive alternative strategy that relies on usage of short peptide fragments to engineer the induction of highly targeted immune responses, consequently avoiding allergenic and/or reactogenic sequences. Conversely, peptide vaccines used in isolation are often weakly immunogenic and require particulate carriers for delivery and adjuvanting. In this article, we discuss the specific advantages and considerations in targeted induction of immune responses by peptide vaccines and progresses in the development of such vaccines against various diseases. Additionally, we also discuss the development of particulate carrier strategies and the inherent challenges with regard to safety when combining such technologies with peptide vaccines.

References

May 1, 1990·The Journal of Experimental Medicine·P AicheleM Schulz
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·W M KastC J Melief
Jan 1, 1989·Cold Spring Harbor Symposia on Quantitative Biology·P Panina-BordignonA Lanzavecchia
Jul 1, 1995·The Journal of Experimental Medicine·P AicheleH Pircher
Oct 1, 1993·Journal of Medical Microbiology·D Sesardic
Oct 26, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·W J van DrielJ B Trimbos
Jul 25, 2000·Journal of Molecular Biology·O MichielinM Karplus
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sander ZwavelingCornelis J M Melief
Aug 31, 2002·Regulatory Toxicology and Pharmacology : RTP·Paul BaldrickAlan W Wheeler
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·W Nicholas HainingMichael S von Berwelt-Baildon
Oct 14, 2004·Immunology and Cell Biology·Nikolai Petrovsky, Julio César Aguilar
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael G AgadjanyanDavid H Cribbs
Sep 10, 2005·International Journal of Cancer. Journal International Du Cancer·Marij J P WeltersRienk Offringa
Oct 8, 2005·Expert Review of Proteomics·Christine Hager-Braun, Kenneth B Tomer
Feb 24, 2006·Cancer Immunology, Immunotherapy : CII·Paal F BrunsvigGustav Gaudernack
Apr 8, 2006·International Journal of Pharmaceutics·R CortesiR Manservigi
Nov 2, 2006·Current Drug Delivery·Ming Tao LiangIstvan Toth
Nov 28, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Akira HayashiShinsaku Nakagawa
Nov 30, 2006·Wiener klinische Wochenschrift·Nicole WesterfeldRinaldo Zurbriggen
Mar 6, 2007·Vaccine·J C Aguilar, E G Rodríguez
May 3, 2007·Nature Reviews. Drug Discovery·Anthony W PurcellJamie Rossjohn
May 23, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Jonathan M GershoniYael Weiss
Jun 19, 2007·Nature Reviews. Microbiology·Stephen M Todryk, Adrian V S Hill
Aug 3, 2007·Expert Review of Vaccines·Martijn S BijkerSjoerd H van der Burg

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Citations

May 7, 2016·International Journal of Molecular Sciences·Ashesh Nandy, Subhash C Basak
Jun 3, 2016·Expert Review of Anticancer Therapy·Nicole A P LiebermanCourtney A Crane
Mar 10, 2016·Current Opinion in Biotechnology·Marie BeitelsheesBlaine A Pfeifer
Jun 25, 2016·The Journal of General Virology·Samuel AdouchiefJussi Hepojoki
Jan 31, 2017·Expert Opinion on Biological Therapy·Amelia LicariGian Luigi Marseglia
Jun 21, 2017·The Journal of General Virology·Maria AnastasinaSarah Butcher
Dec 6, 2017·Journal of Molecular Recognition : JMR·Izabela BehrendtSylwia Rodziewicz-Motowidło
Dec 13, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hernando CurtidorManuel E Patarroyo
Feb 3, 2015·Current Protocols in Microbiology·Peter Michael Moyle
Jul 10, 2018·PLoS Neglected Tropical Diseases·Amanda FritzenOla Blixt
Aug 8, 2018·Human Vaccines & Immunotherapeutics·Ephrem Debebe ZegeyePål Puntervoll
Aug 24, 2018·Biomolecules·Fatma Gizem AvciElif Ozkirimli
Sep 28, 2018·Proteins·Niloofar KhairkhahAzam Bolhassani
Feb 9, 2018·Scientific Reports·Dasun WagachchiThomas Proft
Nov 13, 2018·Current Topics in Medicinal Chemistry·Ashesh NandySubhash C Basak
Oct 4, 2018·Current Computer-aided Drug Design·Sherly Kurnia DewiVivitri Dewi Prasasty
Apr 23, 2019·Journal of Peptide Science : an Official Publication of the European Peptide Society·Lucas R MelloEmerson R Silva
Sep 22, 2017·Human Vaccines & Immunotherapeutics·Patrick M ReevesMark C Poznansky
Dec 14, 2016·Immunity, Inflammation and Disease·Risini D WeeratnaHeather L Davis
Jan 23, 2020·Immunity, Inflammation and Disease·Afshana QuadiriAgam P Singh
Nov 7, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Zhaogang YangBetty Y S Kim
May 10, 2020·Molecular Carcinogenesis·Michele M Hoffmann, Jill E Slansky
Jul 18, 2020·Journal of Biomolecular Structure & Dynamics·Abdus SamadMd Shahedur Rahman
May 18, 2016·The Journal of Biological Chemistry·Prasun KunduAmit Kumar Das
Apr 30, 2017·Chemical Science·Lev A Dykman, Nikolai G Khlebtsov
Jan 9, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Narjes Jafari, Saeid Abediankenari
Aug 17, 2016·Biotechnology Journal·Momoko KitaokaMasahiro Goto
Apr 18, 2017·Acta Pharmacologica Sinica·Shuyun DongMingnan Chen
Sep 9, 2017·Scientific Reports·Bizhan RomaniElham Allahbakhshi
Feb 1, 2016·Chemical Science·Mariusz Skwarczynski, Istvan Toth

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Methods Mentioned

BETA
nuclear
X-ray

Software Mentioned

SMM
BIMAS
PROPRED
BEEPro
BLAST
EPCES
MimoPro
Pepitope
EPSVR
CBTOPE

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