Peptide vaccines prevent tumor growth by activating T cells that respond to native tumor antigens.

Proceedings of the National Academy of Sciences of the United States of America
Kimberly R JordanJ E Slansky

Abstract

Peptide vaccines enhance the response of T cells toward tumor antigens and represent a strategy to augment antigen-independent immunotherapies of cancer. However, peptide vaccines that include native tumor antigens rarely prevent tumor growth. We have assembled a set of peptide variants for a mouse-colon tumor model to determine how to improve T-cell responses. These peptides have similar affinity for MHC molecules, but differ in the affinity of the peptide-MHC/T-cell receptor interaction with a tumor-specific T-cell clone. We systematically demonstrated that effective antitumor responses are generated after vaccination with variant peptides that stimulate the largest proportion of endogenous T cells specific for the native tumor antigen. Importantly, we found some variant peptides that strongly stimulated a specific T-cell clone in vitro, but elicited fewer tumor-specific T cells in vivo, and were not protective. The T cells expanded by the effective vaccines responded to the wild-type antigen by making cytokines and killing target cells, whereas most of the T cells expanded by the ineffective vaccines only responded to the peptide variants. We conclude that peptide-variant vaccines are most effective when the peptides react w...Continue Reading

References

Apr 1, 1995·The Journal of Experimental Medicine·C PfeifferK Bottomly
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·A Y HuangE M Jaffee
Mar 3, 1997·The Journal of Experimental Medicine·M TheobaldL A Sherman
Dec 11, 1999·International Immunology·D ValmoriP Romero
Feb 13, 2001·European Journal of Immunology·N Vest HansenS Buus
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K E de VisserA M Kruisbeek
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas K HoffmannAlbert B DeLeo
Oct 18, 2002·Biopolymers·Roshni SundaramPravin T P Kaumaya
Oct 7, 2003·Nature Medicine·Valerie RubioPeter P Lee
Oct 29, 2003·Journal of Immunological Methods·Michael R BettsRichard A Koup
Mar 23, 2004·Annual Review of Immunology·Gavin P DunnRobert D Schreiber
Apr 20, 2004·PLoS Biology·Frances CrawfordJohn W Kappler
Aug 17, 2004·Cancer Immunology, Immunotherapy : CII·Luisa NovellinoGiorgio Parmiani
Dec 4, 2004·PLoS Medicine·Tor B StugePeter P Lee
Feb 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yibing WangJohn W Kappler
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Oleg Y BorbulevychBrian M Baker
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven A RosenbergSeth M Steinberg
Apr 21, 2006·Immunological Reviews·Frances CrawfordJohn W Kappler
Aug 26, 2006·The Journal of Clinical Investigation·Rachel H McMahanJill E Slansky
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven M TruscottTed H Hansen
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Charles J Kroger, Martha A Alexander-Miller
Dec 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kimberly R JordanJill E Slansky
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yafei HouLawrence Fong
Mar 11, 2008·Vaccine·Jennifer A McWilliamsJill E Slansky
Apr 1, 2009·The Journal of Experimental Medicine·Gabrielle A RizzutoAlan N Houghton

❮ Previous
Next ❯

Citations

Feb 22, 2012·Cancer Immunology, Immunotherapy : CII·Kimberly R JordanJill E Slansky
Sep 1, 2012·Immunologic Research·Jonathan D Buhrman, Jill E Slansky
Oct 10, 2013·The Journal of Biological Chemistry·Jonathan D BuhrmanJill E Slansky
Nov 5, 2010·Clinical and Vaccine Immunology : CVI·Luigi BuonaguroFranco M Buonaguro
Sep 22, 2010·PLoS Biology·Jill E Slansky, Kimberly R Jordan
Sep 14, 2010·Trends in Immunology·Ted H HansenDaved H Fremont
Jun 14, 2016·Human Vaccines & Immunotherapeutics·R Servín-BlancoK Manoutcharian
Jan 5, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tania Løve AaesPeter Vandenabeele
May 10, 2020·Molecular Carcinogenesis·Michele M Hoffmann, Jill E Slansky
Jul 3, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katherine A WaughJill E Slansky
Sep 24, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Charles B KemmlerJill E Slansky
Jun 3, 2021·Proceedings of the National Academy of Sciences of the United States of America·Pengcheng WeiLei Yin
Jun 18, 2021·Science Translational Medicine·Mario FidanzaAlbert J Wong
Jul 17, 2021·Journal for Immunotherapy of Cancer·Erkko YlösmäkiVincenzo Cerullo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

Seminars in Cancer Biology
Rachel H McMahan, J E Slansky
The Journal of Immunology : Official Journal of the American Association of Immunologists
Charles B KemmlerJ E Slansky
© 2021 Meta ULC. All rights reserved