Peptide YY kinetics and effects on blood pressure and circulating pancreatic and gastrointestinal hormones and metabolites in man

The Journal of Clinical Endocrinology and Metabolism
T E AdrianS R Bloom

Abstract

Peptide YY (PYY) is a 36 amino acid peptide produced by mucosal endocrine cells of the ileum and colon which inhibits acid secretion and intestinal transit in man. To assess its effects on metabolites and digestive hormones PYY was infused into 18 fasting normal subjects at three dose levels (0.06, 0.19, and 0.57 pmol kg-1 min-1), each for a period of 1 h. During the infusions mean plasma PYY levels increased by 8, 25, and 73 pmol/liter, respectively. The mean disappearance half-time on stopping the infusions was 9.2 +/- 0.4 (SEM) min. The mean MCR was 7.3 +/- 0.7 ml kg-1 min-1 and the apparent volume of distribution was calculated to be 94 +/- 9 ml kg-1. During the highest dose infusion there was a significant increase in both systolic and diastolic blood pressure, of 8.6 +/- 3.7 mmHg (P less than 0.05) and 10.9 +/- 3.0 mmHg (P less than 0.01), respectively. PYY caused a significant 50% reduction in plasma pancreatic polypeptide concentrations (P less than 0.05) and a 55% reduction in circulating motilin levels (P less than 0.05). PYY had no significant effect on circulating concentrations of insulin, glucagon, gastrin, gastric inhibitory peptide, neurotensin, enteroglucagon, or vasoactive intestinal peptide. PYY also had no s...Continue Reading

Citations

Jul 15, 1987·Experientia·R A Goodlad, N A Wright
Mar 1, 2012·Diabetes, Obesity & Metabolism·L ZhangH Herzog
Aug 1, 1988·Mayo Clinic Proceedings·L T ShusterF J Service
Aug 5, 2009·Regulatory Peptides·A-B WitteP T Schmidt
Dec 7, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Tom BillyardSudhesh Kumar
Oct 9, 2007·Regulatory Peptides·Hiroaki UenoMasamitsu Nakazato
Jan 11, 2007·Peptides·Dana BoeyHerbert Herzog
May 11, 2013·Current Biology : CB·Adam P ChambersRandy J Seeley
Aug 12, 2016·Metabolic Syndrome and Related Disorders·Sasa DusanovSerena Tonstad
Nov 29, 2016·Critical Reviews in Food Science and Nutrition·Giovanna MuscogiuriAnnamaria Colao
Jul 13, 2005·European Journal of Clinical Investigation·U Hanusch-Enserer, M Roden
Nov 2, 2006·Endocrine Reviews·Kevin G MurphyStephen R Bloom
Jan 29, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Signe TorängJens Juul Holst
Jan 22, 2019·Frontiers in Endocrinology·Emily W L SunDamien J Keating
Mar 7, 2021·Nutrients·Valentina RovellaManfredi Tesauro
Mar 19, 2020·Cell Metabolism·Ruth E GimenoRandy J Seeley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.