Peptide YY release by fatty acids is sufficient to inhibit gastric emptying in dogs

Gastroenterology
T N PappasI L Taylor

Abstract

Peptide YY is a candidate enterogastrone localized to endocrine cells of the ileocolonic mucosa. The purpose of the present study was to determine if blood levels of peptide YY observed after perfusion of the intestine with fatty acids are capable of slowing gastric emptying. Gastric emptying of a 300-ml saline meal was monitored during intravenous infusion of normal saline or graded doses of peptide YY. Gastric emptying was significantly inhibited by infusion of peptide YY in doses of 200 and 400 pmol/kg X h. During the saline control study, 229 +/- 12 ml of the 300-ml saline meal emptied by 10 min. This figure was reduced (p less than 0.01) to 110 +/- 28 ml by the infusion of peptide YY at a dose of 200 pmol/kg X h. This dose of peptide YY produced plasma concentrations (delta PYY = 239 +/- 50 pM) that were lower than those seen in response to intestinal perfusion of oleic acid (delta PYY = 395 +/- 55 pM) in the same animals. We conclude that perfusion of the intestine with oleic acid releases peptide YY in amounts sufficient to slow gastric emptying.

Citations

Nov 1, 1992·Journal of Gastroenterology and Hepatology·R FraserJ Dent
Apr 13, 1999·The American Journal of Physiology·T NozuY Taché
May 26, 2001·Annual Review of Nutrition·P TsoA B Thomson
Oct 17, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Keishi KawakuboYvette Taché
Jan 1, 1990·Nutrition Research Reviews·A G Low
Jan 1, 1991·Scandinavian Journal of Gastroenterology·R LethL Olbe
Jun 1, 1997·Scandinavian Journal of Gastroenterology·A WettergrenJ J Holst
Jun 12, 1999·Scandinavian Journal of Gastroenterology·P L van BattumJ B Jansen
Mar 10, 2001·The Journal of Nutrition·J B van GoudoeverD G Burrin
Mar 29, 2002·Clinical and Experimental Pharmacology & Physiology·Tuğba TopçuCumhur Yeğen
Sep 8, 1998·The American Journal of Physiology·C M BreenB A Benjamin
Aug 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·H YangY Taché
Sep 25, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Timothy H MoranEllen E Ladenheim
Aug 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Niels VrangPhilip Just Larsen
Jun 16, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R A PittnerA A Young
Jul 1, 1994·Digestive Diseases and Sciences·Z DreznikN J Soper
Jan 21, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Umberto LaforenzaUlderico Ventura
Mar 23, 2007·BMC Gastroenterology·Jón O KristinssonJoost P H Drenth
Jul 10, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Prasanth K ChelikaniRoger D Reidelberger
Sep 10, 2009·Journal of Peptide Science : an Official Publication of the European Peptide Society·Søren L PedersenKnud J Jensen
Jan 6, 2010·Chembiochem : a European Journal of Chemical Biology·Søren L PedersenKnud J Jensen
Dec 17, 2008·Nutrition Research Reviews·G BoschM W A Verstegen
Jul 1, 1993·Journal of Dairy Science·I L Taylor
Aug 1, 1996·European Journal of Clinical Investigation·W M SunM Horowitz
Jan 24, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·P JanssenJ Tack
Aug 1, 1995·Digestive Diseases and Sciences·M F OttersonJ E Moulder
Jun 1, 1995·Scandinavian Journal of Gastroenterology·P PlaisanciéJ C Cuber
Dec 17, 2014·The Proceedings of the Nutrition Society·Edward S ChambersGary Frost
Oct 30, 2004·Scandinavian Journal of Gastroenterology·W P M HopmanJ B M J Jansen
Aug 13, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S PellissierC Jarrousse
Aug 4, 2011·Equine Veterinary Journal. Supplement·D G M SuttonS Love
Nov 24, 1999·The American Journal of Physiology·T J KalogerisP Tso
Mar 1, 1997·The Journal of Nutrition·T J KalogerisP Tso
Feb 5, 2002·Peptides·Takenori OnagaSeiyu Kato

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