Peptide YY signaling in the lateral parabrachial nucleus increases food intake through the Y1 receptor

American Journal of Physiology. Endocrinology and Metabolism
Amber L AlhadeffHarvey J Grill

Abstract

Although central PYY delivery potently increases food intake, the sites of action and mechanisms mediating these hyperphagic effects are not fully understood. The present studies investigate the contribution of lateral parabrachial nucleus (lPBN) PYY-Y receptor signaling to food intake control, as lPBN neurons express Y receptors and receive PYY fibers and are known to integrate circulating and visceral sensory signals to regulate energy balance. Immunohistochemical results identified a subpopulation of gigantocellular reticular nucleus PYY-producing neurons that project monosynaptically to the lPBN, providing an endogenous source of PYY to the lPBN. lPBN microinjection of PYY-(1-36) or PYY-(3-36) markedly increased food intake by increasing meal size. To determine which receptors mediate these behavioral results, we first performed quantitative real-time PCR to examine the relative levels of Y receptor expression in lPBN tissue. Gene expression analyses revealed that, while Y1, Y2, and Y5 receptors are each expressed in lPBN tissue, Y1 receptor mRNA is expressed at fivefold higher levels than the others. Furthermore, behavioral/pharmacological results demonstrated that the hyperphagic effects of PYY-(3-36) were eliminated by l...Continue Reading

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Feb 23, 2018·Nature Reviews. Neuroscience·Ki-Suk KimDarleen A Sandoval
Dec 1, 2017·Nature Neuroscience·Erica RodriguezFan Wang
Feb 7, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nathaneal J HustonRobert C Ritter
Jan 17, 2021·Medicina·Abdelaziz GhanemiJonny St-Amand
Mar 13, 2021·Trends in Endocrinology and Metabolism : TEM·Léa MontégutGuido Kroemer
Jun 22, 2021·The Journal of Physiology·Orla R M WoodwardJo E Lewis

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