Nov 1, 1992

Peptidergic innervation of human salivary glands (parotid gland and submandibular gland)

HNO
C E Hauser-KronbergerG W Hacker

Abstract

Immunocytochemistry and a radioimmunoassay were used to investigate the existence and distributions of various regulatory peptide immunoreactivities (ir) in human submandibular and parotid glands. Numerous nerve fibers containing vasoactive intestinal polypeptide (VIP) and peptide histidine methionine (PHM), or neuropeptide tyrosine (NPY) and C-flanking peptide of NPY (CPON)-ir were found in close proximity to acini, ducts and blood vessels. Only a few calcitonin gene-related peptide (CGRP)- and substance P (SP)-ir nerve fibers could be demonstrated and were mainly localized around blood vessels and ducts. Galanin and the recently discovered peptides helospectin and pituitary adenylate cyclase activating peptide were unable to be detected in the salivary glands studied. Preliminary quantitative investigations of four human submandibular glands using radioimmunoassay showed that VIP-ir had the highest concentration, followed by NPY-ir and CGRP-ir; SP-concentrations were below the detection limit. The possible physiological significance of these peptides for salivary secretion is discussed.

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Mentioned in this Paper

CALCA gene
Calcitonin Gene-Related Peptide
CALCA wt Allele
Cerebellar Mossy Fibers
Muscle Innervation, Function
Blood Vessel
Secretion of Saliva
Mixed Salivary Gland Tumor
Nerve Fibers
Immunocytochemistry

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