PMID: 2126362Jan 1, 1990Paper

Peptidergic innervation of the cerebral circulation. Role in subarachnoid hemorrhage in man

Neurosurgical Review
L EdvinssonR Juul

Abstract

The present paper reviews recent studies in monkey and man adding further to understanding of the role of perivascular peptides in the pathophysiology of subarachnoid haemorrhage. 1. The perivascular fibers, sympathetic fibers (storing noradrenaline, neuropeptide Y), parasympathetic fibers (storing acetylcholine, vasoactive intestinal peptide, peptide histidine methionine and neuropeptide Y) and sensory fibers (storing tachykinins, calcitonin gene-related peptide) were traced using True Blue in monkey. 2. Tracing studies of the monkey middle-cerebral artery (MCA) innervation confirmed earlier studies in rats and cats, with superior cervical and trigeminal ganglia as main immunostaining areas, and contralateral involvement in the superior cervical and trigeminal ganglia. Sphenopalatine immunostaining was scarce. 3. The release of neuropeptides in the external jugular vein in humans in the postoperative course after subarachnoid hemorrhage, using radioimmunoassay, was correlated to hemodynamical changes (vasoconstriction) monitored with Doppler ultrasound on middle cerebral (MCA) and internal carotid arteries (ICA)). 4. Neuropeptide Y-like immunoreactivity (NPY-LI) levels were increased compared to controls in patients with hemod...Continue Reading

References

Mar 1, 1975·Lancet·B Jennett, M Bond
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Feb 1, 1989·Journal of the Autonomic Nervous System·R UddmanL Edvinsson
Jan 1, 1988·Acta neurochirurgica. Supplementum·K F LindegaardP Nakstad
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J McCullochL Edvinsson
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May 1, 1986·Stroke; a Journal of Cerebral Circulation·B B WaltersM A Moskowitz
Feb 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L EdvinssonR Uddman
Jul 13, 1974·Lancet·G Teasdale, B Jennett
Jan 1, 1972·Zeitschrift für Zellforschung und mikroskopische Anatomie·L EdvinssonB Sporrong
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Sep 1, 1994·Journal of the Autonomic Nervous System·L EdvinssonS Gulbenkian

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Citations

Aug 24, 1999·Neurochemistry International·P Sándor
Apr 20, 2001·Progress in Neurobiology·E Farkas, P G Luiten
Aug 14, 2009·Cephalalgia : an International Journal of Headache·C KruuseJ Olesen
Sep 1, 1992·Journal of Neurosurgery·R M PlutaE H Oldfield
Jun 1, 2011·Acta neurochirurgica·Karl-Michael SchebeschMartin Proescholdt
Jul 21, 2016·Journal of Neurosurgical Anesthesiology·Karl-M SchebeschMartin Proescholdt
Aug 7, 2013·Neurological Research·Karl-Michael SchebeschMartin Proescholdt
Sep 26, 2019·Expert Opinion on Biological Therapy·Bianca RaffaelliUwe Reuter

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