PMID: 6172750Nov 4, 1981Paper

Peptidergic innervation of the mammalian sinus nodes: vasoactive intestinal polypeptide, neurotensin, substance P

Neuroscience Letters
E Weihe, M Reinecke

Abstract

By the use of the peroxidase--antiperoxidase (PAP) technique in the sinus node of several mammalian species, vasoactive intestinal polypeptide (VIP), neurotensin (NT) and substance P (SP) immunoreactive structures were detected. VIP and NT as well as SP immunoreactive fibers were found in close association to the vasculature. While the innervation by SP immunoreactive fibers was restricted to blood vessels, VIP and NT immunoreactive fibers and varicosities were also in contact to nodal cells. Juxtanodal intracardiac ganglia and single intranodal ganglionic cells were supplied by VIP, NT and SP immunoreactive varicosities. In addition, VIP immunoreactive perikarya were present. The results suggest an involvement of VIP, NT and SP in the regulation of sinus node blood flow, in impulse generation as well as in extrinsic and intrinsic cardiac reflex mechanisms.

References

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Citations

Jan 8, 2000·Clinical Cardiology·L Feliciano, R J Henning
Oct 1, 1996·Naunyn-Schmiedeberg's Archives of Pharmacology·J SeebeckS Herzig
Jan 1, 1983·Anatomy and Embryology·B BaeckerW G Forssmann
Dec 1, 1991·Biulleten' eksperimental'noĭ biologii i meditsiny·V M PokrovskiĭA N Kurzanov
Apr 1, 1988·Biulleten' eksperimental'noĭ biologii i meditsiny·N A SokolovaE P Iarova
Jul 15, 1987·Experientia·J Wharton, S Gulbenkian
Sep 1, 1996·Pflügers Archiv : European journal of physiology·F Tiaho, J M Nerbonne
Sep 1, 1986·Journal of the Autonomic Nervous System·L RechardtK Kyösola
Mar 1, 1986·Journal of the Autonomic Nervous System·M W HouglandA E Hougland
Oct 1, 1986·Journal of the Autonomic Nervous System·M J KilbornD I McCloskey
Sep 1, 1988·Journal of the Autonomic Nervous System·D B Hoover, J C Hancock
Mar 2, 1995·Journal of the Autonomic Nervous System·K Tanaka, T Chiba
May 1, 1994·Journal of the Autonomic Nervous System·P A Steele, J K Choate
Jan 5, 1996·Journal of the Autonomic Nervous System·P A SteeleJ L Morris
Sep 1, 1982·Peptides·R QuirionF Rioux
May 1, 1982·Peptides·R Quirion
Oct 9, 1989·Neuroscience Letters·P Bałuk, G Gabella

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