Peptidergic nerves in Hirschsprung's disease and its allied disorders

European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie
R TomitaY Kurosu

Abstract

To clarify the significance of peptidergic nerves in Hirschsprung's disease (aganglionosis), hypoganglionosis, and neuronal intestinal dysplasia (NID), we investigated enteric nerve responses in colonic tissues obtained from patients with these diseases. Colonic tissue specimens were obtained from 12 patients with aganglionosis, 8 patients with hypoganglionosis, and 6 patients with NID. Colon specimens from 20 patients without constipation were used as controls. A mechanograph was used to evaluate in vitro colonic responses to electrical field stimulation (EFS) of the adrenergic and cholinergic nerve blockers and gastrointestinal hormones. The following results were obtained: (1) Non-adrenergic inhibitory nerves were found to act on the normal human colon and to a lesser extent in colons with hypoganglionosis or NID, but had no effect on the enteric nerves in colons with aganglionosis. (2) Peptidergic neurotransmitters such as VIP, substance P, and neurotensin apparently act in the normal human colon, and to a lesser extent in the colons with hypoganglionosis or NID, but their effect was almost absent in aganglionosis. (3) VIP acts via neural mechanisms, while substance P and neurotensin may act both via nerves and also directl...Continue Reading

Citations

Mar 31, 2004·Transplantation Proceedings·R TomitaK Tanjoh
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche
May 31, 2013·The Onderstepoort Journal of Veterinary Research·Colin Musara, Camille Vaillant
Oct 9, 2002·World Journal of Surgery·Ryouichi TomitaMasahiro Fukuzawa
Oct 27, 2007·Pediatric Surgery International·Anne-Marie O' Donnell, Prem Puri

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