Peptides and hormesis

Critical Reviews in Toxicology
Abba J Kastin, Weihong Pan

Abstract

Biology is replete with examples of hormesis, the term introduced and developed by Calabrese. The corresponding concept in the field of peptide research has been characterized as the inverted U-shaped dose-response relationship. The articles by Calabrese in this issue summarize the notable progress occurring in the past three decades. In contrast to the skepticism encountered when we introduced this concept for peptides in the early 1970s, hormesis is now becoming recognized as characteristic of many actions of these small proteins. Calabrese is performing a considerable service by his strong advocacy and promotion of the concept to a more general readership. Hopefully, hormesis will be routinely considered in the design of research projects and the discovery of pharmaceutical agents.

References

Jan 1, 1976·Pharmacology, Biochemistry, and Behavior·R H Ehrensing, A J Kastin
May 1, 1978·The American Journal of Psychiatry·R H Ehrensing, A J Kastin
Jul 30, 1979·Life Sciences·A J KastinD H Coy
May 1, 1990·Peptides·J G McCoy, D D Avery
Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·C Hara, A J Kastin
Jan 1, 1974·Archives of General Psychiatry·R H Ehrensing, A J Kastin
Jan 1, 1973·Neuroendocrinology·N P PlotnikoffA V Schally
Nov 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·N P PlotnikoffA V Schally
Jan 1, 1984·Peptides·A J KastinM V Graf
Nov 1, 1984·Pharmacology, Biochemistry, and Behavior·A J KastinM V Graf
Aug 22, 2001·Peptides·M J WaynerJ W Harding
Jul 10, 2002·Human & Experimental Toxicology·E J Calabrese, L A Baldwin
Jul 20, 2002·Peptides·Giuseppe ClementiMatilde Amico-Roxas
Nov 19, 2005·Peptides·Susan A FarrJohn E Morley

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Citations

Dec 12, 2012·PloS One·Songfa ZhongRichard P Ebstein
Jun 28, 2014·Current Opinion in Pharmacology·Klára Gyires, Zoltán S Zádori
Jan 31, 2012·Neurobiology of Aging·Daniela PuzzoAgostino Palmeri
Oct 3, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mirna BradamanteAna Kozmar
Mar 26, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vladimir BlagaićFilip Culo
Oct 13, 2012·Human & Experimental Toxicology·E J CalabreseV Calabrese
Jun 30, 2009·Neurochemical Research·María G López Ordieres, Georgina Rodríguez de Lores Arnaiz
Jan 1, 2017·Brain Circulation·Edward J CalabreseJames Giordano

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