Peptides and neuromas: calcitonin gene-related peptide, substance P, and mast cells in a mechanosensitive human sural neuroma

Muscle & Nerve
D W ZochodneG Sutherland

Abstract

We examined and compared a mechanosensitive human sural neuroma and a contralateral sural nerve collected simultaneously from a patient involved in a diabetic neuropathy research protocol. Using indirect immunofluorescence staining. we identified a striking difference in the content within axons of two neuropeptides, substance P (SP) and calcitonin, gene-related peptide (CGRP), between the contralateral nerve and the neuroma. Unlike the contralateral nerve, where immunofluorescence was sparse, a significant number of disorganized axon profiles that stained brightly positive for CGRP or SP were identified in the neuroma. In contrast, staining for tyrosine hydroxylase, a label of sympathetic axons, was largely absent except around one large arteriole. The neuroma specimen also contained large numbers of serotonin-containing mast cells, only noted occasionally in the contralateral nerve. The peptide staining and mast cell accumulation in the human neuroma closely resembled changes we have previously observed in an animal neuroma model. Local neuropeptides may play a role in the injury response of peripheral nerve, and may be related to mechanosensitivity.

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Citations

Jan 25, 2012·Immunopharmacology and Immunotoxicology·Markus RitterKlas Nordlind
Jul 31, 2013·Hand Clinics·David M Brogan, Sanjeev Kakar
May 19, 2009·Journal of Comparative Pathology·G Kastengren FröbergK Nordlind
Jan 8, 2008·Experimental Dermatology·Klas NordlindAndrzej Slominski
Mar 18, 2005·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Amit R VoraPeter P Robinson
Nov 14, 2006·Archives of Oral Biology·Amit R VoraFiona M Boissonade
Apr 1, 2016·Journal of the American Podiatric Medical Association·Hyun SeokSung Won Park
May 30, 2001·Brain Research·D W ZochodneK A Sharkey
Jan 3, 2001·Muscle & Nerve. Supplement·D W Zochodne
Nov 13, 2004·Journal of Neuropathology and Experimental Neurology·Xia-Qing LiDouglas W Zochodne

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