Jan 1, 1985

Peptides as modifiers of Na+-induced pinocytosis in starved Amoeba proteus

Peptides
J O Josefsson, P Johansson

Abstract

Low concentrations of six peptide hormones; glucagon, vasoactive intestinal peptide, substance P, angiotensin II, lysine-vasopressin, arginine-vasopressin, and the chemotactic peptide fMet-Leu-Phe, activated the capacity for pinocytosis in starved Amoeba proteus. Competitive inhibitors of the chemotactic peptide in leucocytes inhibited activation by fMet-Leu-Phe, suggesting that its action in the amoeba is mediated by specific receptors. The opioid peptides, beta-endorphin, dynorphin (1-13) and leu-enkephalin abolished through a naloxone-sensitive mechanism activation by hormones and several other activating agents. Also, low concentrations of beef and pork insulin inhibited activation by peptide hormones. An insulin analogue of low potency in mammalian cells was inactive in the amoeba. These results support the hypothesis that besides opioid receptors, there may be insulin receptors and possibly receptors for several other peptide hormones in Amoeba proteus.

  • References8
  • Citations1

References

  • References8
  • Citations1

Citations

Mentioned in this Paper

Endorphins
Hormone Receptors, Cell Surface
Amoeba genus
Insulin B Chain
Novolin
Sodium
Polypeptides
Metazoa
Pinocytosis

About this Paper

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