Peptides as protein binding site mimetics

Current Opinion in Chemical Biology
Jutta Eichler

Abstract

The rational/structure-based design and/or combinatorial development of molecules capable of structurally and functionally mimicking the binding sites of proteins represents a promising strategy for the exploration and understanding of protein structure and function. The ultimate goal of using such molecules is the modulation of protein function through controlled interference with the underlying binding events. In addition to their basic significance, such proteinmimetics are also useful tools for a range of biomedical applications, in particular the inhibition of disease-associated protein-ligand interactions. Owing to their chemical and structural relation to proteins, as well as the relative simplicity of their chemical or recombinant synthesis, peptides have emerged as adequate molecules for the mimicry of protein binding sites, as well as the inhibition of protein-protein interactions.

References

Feb 23, 1996·The Journal of Biological Chemistry·E Pérez-PayáSylvie E Blondelle
Nov 4, 1998·Journal of Molecular Biology·Clemencia PinillaN S Greenspan
Oct 3, 1999·Journal of Medicinal Chemistry·Richard A HoughtenJ M Ostresh
Mar 29, 2002·Chembiochem : a European Journal of Chemical Biology·Judit VillénDavid Andreu
Nov 20, 2003·Journal of the American Chemical Society·Stacey E RutledgeAlanna Schepartz
Jan 8, 2004·Journal of the American Chemical Society·Dasantila Golemi-KotraAlanna Schepartz
Aug 18, 2004·Current Opinion in Structural Biology·Richard P Cheng
Aug 18, 2004·Journal of Molecular Biology·Eva S CobosJose C Martinez
Sep 30, 2004·Organic & Biomolecular Chemistry·Raimo FrankeJutta Eichler
Dec 21, 2005·Applied Microbiology and Biotechnology·Matthias Paschke
Jan 7, 2006·Chembiochem : a European Journal of Chemical Biology·Joshua A KritzerAlanna Schepartz
Mar 7, 2006·Journal of Clinical Microbiology·Joanne L CaseyMichael Foley
Jul 21, 2006·Biochemical and Biophysical Research Communications·César BoggianoSylvie E Blondelle
Nov 23, 2006·Journal of Receptor and Signal Transduction Research·Raimo FrankeJutta Eichler
Nov 30, 2006·Journal of Virological Methods·Osmany G LarraldeEla M Perez
Jan 11, 2007·Angewandte Chemie·Raimo FrankeJutta Eichler
Feb 6, 2007·Vaccine·Tumenjargal SharavPeter Walden
Jul 24, 2007·Current Opinion in Biotechnology·Arne Skerra
Aug 24, 2007·The Biochemical Journal·Béatrice LaudetClaude Cochet
Sep 18, 2007·Current Opinion in Structural Biology·Sachdev S Sidhu, Shohei Koide
Sep 22, 2007·Chembiochem : a European Journal of Chemical Biology·Dirk-Jan van ZoelenRob M J Liskamp
Oct 16, 2007·Vaccine·Joseph B LegutkiLeslie W Baillie
Dec 13, 2007·Journal of Molecular Recognition : JMR·Peter TimmermanRob H Meloen
Apr 17, 2008·Accounts of Chemical Research·John A Robinson

Citations

Feb 23, 2010·Journal of Combinatorial Chemistry·Zhigang XuPaul W Baures
Dec 14, 2012·Journal of the Royal Society, Interface·Panagiotis L Kastritis, Alexandre M J J Bonvin
Dec 5, 2012·Beilstein Journal of Organic Chemistry·Julia MeierJutta Eichler
Mar 24, 2011·Future Medicinal Chemistry·Hadar Benyamini, Assaf Friedler
Mar 19, 2014·Organic & Biomolecular Chemistry·Arne BerthelmannJutta Eichler
Feb 3, 2016·Frontiers in Bioengineering and Biotechnology·Andrea GroßJutta Eichler
Mar 23, 2011·Current Opinion in Chemical Biology·John A Robinson
Dec 4, 2010·International Journal of Cancer. Journal International Du Cancer·Abdus Faham, Joseph G Altin
Jun 17, 2010·Journal of Peptide Science : an Official Publication of the European Peptide Society·Maria Teresa ConconiPier Paolo Parnigotto
Jun 1, 2014·Progress in Biophysics and Molecular Biology·Rhonald C LuaOlivier Lichtarge
Jul 23, 2015·Journal of Peptide Science : an Official Publication of the European Peptide Society·Uwe KafurkeJutta Eichler
Jun 13, 2015·Future Medicinal Chemistry·Koushik ChandraAssaf Friedler
Nov 5, 2013·Current Opinion in Chemical Biology·Nir LondonOra Schueler-Furman
Jan 24, 2017·Future Medicinal Chemistry·Aleksandra Ellert-MiklaszewskaBozena Kaminska
Jan 31, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Norman LeoXiangqun Zeng
Jan 27, 2017·Chembiochem : a European Journal of Chemical Biology·Christina HaussnerJutta Eichler
Jun 14, 2012·Chemistry : a European Journal·Kalle MöbiusJutta Eichler
Nov 26, 2009·Chembiochem : a European Journal of Chemical Biology·Edit WéberTamás A Martinek
Feb 3, 2015·Chembiochem : a European Journal of Chemical Biology·Andrea GroßJutta Eichler
Aug 8, 2009·Expert Opinion on Therapeutic Targets·Sonia Kapoor, Dulal Panda
Dec 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ke-Jia WuDik-Lung Ma
Jul 7, 2015·Chembiochem : a European Journal of Chemical Biology·Chie Hashimoto, Jutta Eichler

Related Concepts

Polypeptides
Drug Modeling
Combinatorial Chemistry Techniques
Biomimetic Materials
Ligands
Peptides
Protein Binding
Recombinant Proteins
Site
Chemicals

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.