PMID: 8946687Oct 1, 1996Paper

Peptides bound endogenously by HLA-Cw*0304 expressed in LCL 721.221 cells include a peptide derived from HLA-E

Tissue Antigens
C M TzengL D Barber

Abstract

The peptide-binding specificity of HLA-Cw*0304 was determined. Sequence analysis of endogenously-bound peptides isolated from Cw*0304 expressed by LCL 721.221 (221 for short) cells transfected with Cw*0304 cDNA revealed this class I allotype preferentially binds peptides possessing alanine at position 2 and leucine or methionine at the C-terminus. One peptide isolated from Cw*0304 expressed by 221 cells has sequence identity to residues 116-126 of HLA-E. Expression of HLA-E by 221 cells was confirmed by isolation of mRNA transcripts for HLA-E*0101 and detection of beta 2-microglobulin (beta 2-m)-associated HLA-E protein.

References

Jan 1, 1985·Immunogenetics·C LayetF A Lemonnier
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Y ShimizuR DeMars
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R DeMarsH T Orr
Dec 1, 1995·The Journal of Experimental Medicine·D BarouchH G Rammensee
Jan 1, 1993·Annual Review of Cell Biology·L D Barber, P Parham
Feb 1, 1994·Current Opinion in Immunology·V H Engelhard
Oct 1, 1994·Tissue Antigens·A Steinle, D J Schendel

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Citations

Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·F ZappacostaJ E Coligan
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heather D Hickman-MillerWilliam H Hildebrand

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