Peptides from Antarctic Krill ( Euphausia superba) Improve Osteoarthritis via Inhibiting HIF-2α-Mediated Death Receptor Apoptosis and Metabolism Regulation in Osteoarthritic Mice

Journal of Agricultural and Food Chemistry
Kai WangJingfeng Wang

Abstract

Osteoarthritis (OA) is a prevalent debilitating disease which is predominantly characterized by cartilage degeneration. In the current study, destabilization of the medial meniscus (DMM) mouse model was used to investigate the effects of Antarctic krill peptides (AKP) on cartilage protection. As observed, AKP clearly ameliorate cartilage degeneration as evidenced by increased cartilage thickness and cartilage area and decreased histological Osteoarthritis Research Society International (OARSI) scores. Toluidine blue staining showed that AKO remarkably inhibited the loss of cartilage matrix in mice with OA. Hypoxia-inducible factor-2α (HIF-2α) has a key role in catabolic regulation and inflammation cascades which are the main causes of OA. AKP can down-regulate the expression of HIF-2α and its downstream genes such as MMP-13, Adamts-5, IL-1β, iNOS, CXCL-1, and NOS2. Consistent with this, anabolic genes such as Acan and Col2α1 were restored after treatment with AKP. Chondrocyte apoptosis and the reduction in cartilage cell viability are also involved in the process of OA. The HIF-2α-mediated death receptor apoptosis signaling pathway has been involved in the regulation of chondrocyte apoptosis. AKP can reduce the expressions of k...Continue Reading

References

Oct 1, 1988·Analytical Biochemistry·S A Cohen, D J Strydom
Jan 1, 1997·Annual Review of Medicine·C M Rudin, C B Thompson
Oct 23, 1997·Arthritis and Rheumatism·S HashimotoM Lotz
Mar 13, 1999·The Journal of Biological Chemistry·O MicheauM T Dimanche-Boitrel
Jun 26, 2001·Cell Death and Differentiation·H U KontnyC M Niemeyer
Nov 7, 2002·Journal of the American Veterinary Medical Association·Harold W HannahUNKNOWN American Veterinary Medical Association
Jul 21, 2004·Rheumatic Diseases Clinics of North America·Thomas AignerHelmtrud I Roach
Oct 6, 2004·Expert Opinion on Investigational Drugs·Maria B GrantRobert N Mames
Dec 31, 2005·Arthritis and Rheumatism·Jennifer M Hootman, Charles G Helmick
Jul 13, 2006·Annals of the New York Academy of Sciences·Maurizio PacificiMasahiro Iwamoto
Feb 9, 2008·Cell Death and Differentiation·S A Patel, M C Simon
Dec 2, 2009·Arthritis and Rheumatism·Harry KotlarzJohn A Rizzo
Jan 22, 2010·Apoptosis : an International Journal on Programmed Cell Death·M Almonte-BecerrilJ B Kouri
Jul 21, 2010·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Giuseppe MusumeciGiuseppa Martinez
Mar 23, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yelena L PobezinskayaZheng-gang Liu
Aug 20, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shinya FujitaToshikazu Kubo
Sep 23, 2011·Science Translational Medicine·Erik R SampsonMichael J Zuscik
Nov 1, 2011·Bone·Johanne Martel-PelletierJean-Pierre Pelletier
Feb 15, 2014·BioMed Research International·Subhadeep ChakrabartiJianping Wu
Jul 22, 2014·Scandinavian Journal of Medicine & Science in Sports·G MusumeciA Mobasheri
Sep 30, 2016·Acta Microbiologica Et Immunologica Hungarica·Elena Nikolaevna FilatovaOleg Vladimirovich Utkin
Jul 1, 2017·Annals of the New York Academy of Sciences·Andrey S MarchevMilen I Georgiev
Jan 1, 2018·The American Journal of the Medical Sciences·Zengdong Meng, Rongzhong Huang
Jul 30, 2019·Journal of Food Biochemistry·Snigdha Guha, Kaustav Majumder

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