Peptides in the brain: mass spectrometry-based measurement approaches and challenges.

Annual Review of Analytical Chemistry
Lingjun Li, Jonathan V Sweedler

Abstract

The function and activity of almost every circuit in the human brain are modified by the signaling peptides (SPs) surrounding the neurons. As the complement of peptides can vary even in adjacent neurons and their physiological actions can occur over a broad range of concentrations, the required figures of merit for techniques to characterize SPs are surprisingly stringent. In this review, we describe the formation and catabolism of SPs and highlight a range of mass spectrometric techniques used to characterize SPs. Approaches that supply high chemical information content, direct tissue profiling, spatially resolved data, and temporal information on peptide release are also described. Because of advances in measurement technologies, our knowledge of SPs has greatly increased over the last decade, and SP discoveries will continue as the capabilities of modern measurement approaches improve.

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Citations

Aug 30, 2012·Journal of the American Society for Mass Spectrometry·Kevin R TuckerJonathan V Sweedler
Sep 21, 2012·Journal of the American Society for Mass Spectrometry·Xiaowen HouJonathan V Sweedler
Nov 30, 2012·Journal of the American Society for Mass Spectrometry·Hui YeLingjun Li
Jun 30, 2012·Journal of Proteome Research·Ping YinJonathan V Sweedler
Dec 22, 2012·Journal of Proteome Research·Ji Eun LeeJonathan V Sweedler
Feb 19, 2009·Journal of Proteome Research·Mingming MaLingjun Li
Jun 12, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elena V RomanovaJonathan V Sweedler
May 23, 2012·Molecular BioSystems·Adrian GuthalsNuno Bandeira
Jan 31, 2009·Proceedings of the National Academy of Sciences of the United States of America·Axel BrockmannJonathan V Sweedler
Oct 3, 2012·Molecular & Cellular Proteomics : MCP·Chenxi JiaLingjun Li
Aug 9, 2011·Bioinformatics·Yoona KimNuno Bandeira
Nov 17, 2012·BMC Genomics·Kenneth I PorterSandra L Rodriguez-Zas
Apr 3, 2010·BMC Biology·Fang XieJonathan V Sweedler
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Jan 27, 2015·Biochimica Et Biophysica Acta·Ta-Hsuan OngJonathan V Sweedler
Feb 22, 2011·Frontiers in Neuroendocrinology·Jennifer W MitchellMartha U Gillette

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Methods Mentioned

BETA
dissection
immunoprecipitation
irradiating
peptide fractionation
electrophoresis
acetylation
amidation

Software Mentioned

MassLynx
PepSeq
SEQUEST
PEAKS
NeuroPred
Mascot
SPIDER Solutions
LuteFisk
Mascot Distiller
BLAST

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