PMID: 3755293Jul 1, 1986Paper

Peptides PHI and VIP: comparison between vascular and nonvascular smooth muscle effect in rabbit uterus

The American Journal of Physiology
B BardrumJ Fahrenkrug

Abstract

The distribution and effects of the two neuropeptides, vasoactive intestinal polypeptide (VIP) and peptide histidine isoleucine amide (PHI), on vascular and nonvascular smooth muscle in the urogenital tract of nonpregnant rabbit female, were investigated. Immunoreactive VIP and PHI were present in all regions except the ovary with the highest concentration in the uterine cervix. By using in vitro tension recordings of myometrial specimens, it was demonstrated that both peptides displayed a dose-dependent inhibition of the mechanical activity. The dose-response curves of VIP and PHI were superimposable with and ID50 of 3 X 10(-8) mol/l, and their combined effect was additive. In addition, the influence of the two peptides on myometrial blood flow (MBF) was investigated by the xenon-133 washout technique. Both peptides were found to increase MBF with the same potency and efficacy. Their combined effect was additive. In conclusion VIP and PHI are present in the rabbit urogenital tract, and the two peptides are equipotent inhibitors of mechanical nonvascular and vascular smooth muscle activity in the uterus.

References

Dec 1, 1978·Journal of Neurochemistry·J Fahrenkrug, O B Schaffalitzky de Muckadell
Feb 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M BodanszkyS I Said
Nov 30, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·J Fahrenkrug, J H Pedersen
Sep 10, 1982·European Journal of Pharmacology·J M Lundberg, K Tatemoto
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K Tatemoto, V Mutt
Jun 1, 1981·Acta Physiologica Scandinavica·B Ottesen, J Fahrenkrug

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