Peptides with dual mode of action: Killing bacteria and preventing endotoxin-induced sepsis

Biochimica Et Biophysica Acta
Klaus BrandenburgKarl Lohner

Abstract

Bacterial infections, with the most severe form being sepsis, can often not be treated adequately leading to high morbidity and lethality of infected patients in critical care units. In particular, the increase in resistant bacterial strains and the lack of new antibiotics are main reasons for the worsening of the current situation, As a new approach, the use of antimicrobial peptides (AMPs) seems to be promising, combining the ability of broad-spectrum bactericidal activity and low potential of induction of resistance. Peptides based on natural defense proteins or polypeptides such as lactoferrin, Limulus anti-lipopolysaccharide factor (LALF), cathelicidins, and granulysins are candidates due to their high affinity to bacteria and to their pathogenicity factors, in first line lipopolysaccharide (LPS, endotoxin) of Gram-negative origin. In this review, we discuss literature with the focus on the use of AMPs from natural sources and their variants as antibacterial as well as anti-endotoxin (anti-inflammatory) drugs. Considerable progress has been made by the design of new AMPs for acting efficiently against the LPS-induced inflammation reaction in vitro as well as in vivo (mouse) models of sepsis. Furthermore, the data indicate ...Continue Reading

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Citations

Sep 9, 2017·Chemical Biology & Drug Design·Mohammed Auwal IbrahimAnabella R M Gaspar
Sep 29, 2018·Surgical Infections·Donald E Fry
Dec 26, 2019·Innate Immunity·Jorge Lozano-AponteChristian Alexander
Mar 4, 2020·Current Topics in Medicinal Chemistry·Jiarui LiEster Boix
Mar 7, 2017·Frontiers in Neuroscience·Jianguo LiRoger W Beuerman
Aug 11, 2018·Frontiers in Immunology·Lena HeinbockelKlaus Brandenburg
Apr 13, 2018·Frontiers in Pharmacology·Anja PfalzgraffGünther Weindl
Feb 6, 2021·International Journal of Molecular Sciences·Lena HeinbockelKlaus Brandenburg
Aug 20, 2016·Acta Microbiologica Et Immunologica Hungarica·Laszlo Otvos
Mar 20, 2021·Molecular Therapy. Methods & Clinical Development·Michelle V MouritzenHåvard Jenssen
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Charlotte M J WesselingNathaniel I Martin
Nov 20, 2020·Expert Review of Anti-infective Therapy·Klaus BrandenburgPatrick Garidel
Sep 1, 2021·Peptides·Ernesto M MartellAnselmo J Otero-González

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