Peptidome Analysis of Pancreatic Tissue Derived from T1DM Mice: Insights into the Pathogenesis and Clinical Treatments of T1DM.

BioMed Research International
Fan ZhangWeigang Ji

Abstract

Bioactive peptides attract growing concerns for their participation in multiple biological processes. Their roles in the pathogenesis of type 1 diabetes mellitus remain poorly understood. In this study, we used LC-MS/MS technology to compare the peptide profiling between pancreatic tissue of T1DM mice and pancreatic tissue of matched control groups. A total of 106 peptides were differentially expressed in T1DM pancreatic tissue, including 43 upregulated and 63 downregulated peptides. Most of the precursor proteins are insulin. Further bioinformatics analysis (GO and pathway analysis) indicated that the potential functions of these differential peptides were tightly related to regulation of endoplasmic reticulum stress. In conclusion, this study highlights new candidate peptides and provides a new perspective for exploring T1DM pathogenesis and clinical treatments.

References

Mar 1, 2007·Journal of Diabetes Science and Technology·Firas H El-KhatibEdward R Damiano
Apr 13, 2011·Pediatric Diabetes·Ragnar HanasBarbara Anderson
Sep 29, 2011·International Journal of Clinical Pharmacy·Kyeong-Hye Jeong, Bong Kyu Yoo
Jan 25, 2014·Paediatric Drugs·Faisal S Malik, Craig E Taplin
Nov 4, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jia SunBirgitta Agerberth
Mar 4, 2017·The Indian Journal of Medical Research·Levent DemirtasKultigin Turkmen
Apr 4, 2017·Bosnian Journal of Basic Medical Sciences·Tatsuo Tomita
Jul 20, 2017·Bioorganic & Medicinal Chemistry·Jolene L Lau, Michael K Dunn
Jan 23, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Lance Thielen, Anath Shalev
Feb 8, 2018·Peptides·Ben JonesGuy A Rutter
Jul 17, 2018·Current Diabetes Reviews·Ingrid K Hals
Jul 26, 2018·Digestive Diseases·Navchetan KaurRakesh Kochhar
Aug 4, 2018·Journal of Cellular Biochemistry·Shahrzad NojehdehiSeyed Mahmoud Hashemi
Sep 20, 2018·Diabetes, Obesity & Metabolism·Ming LiuPeter Arvan
May 15, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Henri Honka, Marzieh Salehi
Sep 6, 2019·Apoptosis : an International Journal on Programmed Cell Death·Mengqiu WuZhanjun Jia
Dec 15, 2019·Biomolecules·Sujuan DingJun Fang
Jan 11, 2020·Chinese Medical Journal·Zhao-Hui CaoXiao-Bo Hu
Feb 8, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Giacomo ValliRoss D Neville

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Software Mentioned

proteinpilot
ProtParam
PyMOL Molecular Graphics System
IPA
Ingenuity Pathway Analysis
GraphPad Prism
ProteinpilotTM

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