Peptidyl-prolyl isomerases: a full cast of critical actors in cardiovascular diseases

Cardiovascular Research
Gianluca Lorenzo PerrucciPatrizia Nigro

Abstract

Peptidyl-prolyl cis-trans-isomerases are a highly conserved family of immunophilins. The three peptidyl-prolyl cis-trans-isomerase subfamilies are cyclophilins, FK-506-binding proteins, and parvulins. Peptidyl-prolyl cis-trans-isomerases are expressed in multiple human tissues and regulate different cellular functions, e.g. calcium handling, protein folding, and gene expression. Moreover, these subfamilies have been shown to be consistently involved in several cardiac and vascular diseases including heart failure, arrhythmias, vascular stenosis, endothelial dysfunction, atherosclerosis, and hypertension. This review provides a concise description of the peptidyl-prolyl cis-trans-isomerases and presents an incisive selection of studies focused on their relationship with cardiovascular diseases.

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Citations

May 21, 2015·Biomolecules·Roopa Thapar
Nov 4, 2016·Proteomics·Michael SchumannMiroslav Malešević
Jan 13, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Alba Fernández-SanlésRoberto Elosua
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