Peptidylarginine deiminases and deiminated proteins at the epidermal barrier

Experimental Dermatology
Laura CauMichel Simon

Abstract

Deimination or citrullination is a post-translational modification catalysed by a family of calcium-dependent enzymes called peptidylarginine deiminases (PADs). It corresponds to the transformation of arginine residues within a peptide sequence into citrulline residues. Deimination induces a decreased net charge of targeted proteins; therefore, it alters their folding and changes intra- and intermolecular ionic interactions. Deimination is involved in several physiological processes (inflammation, gene regulation, etc.) and human diseases (rheumatoid arthritis, neurodegenerative diseases, cancer, etc.). Here, we describe the PADs expressed in the epidermis and their known substrates, focusing on their role in the epidermal barrier function.

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Citations

Jul 11, 2018·Experimental Dermatology·Leopold Eckhart, Patrick L J M Zeeuwen
Feb 15, 2019·The New England Journal of Medicine·Liron MalkiEli Sprecher
Jan 19, 2020·International Journal of Molecular Sciences·Marie-Claire MéchinMichel Simon
Dec 31, 2019·Journal of Immunology Research·Mohammed AlghamdiElrashdy M Redwan
Nov 25, 2020·International Journal of Molecular Sciences·Julie BriotMarie-Claire Méchin
Jun 16, 2021·Archives of Dermatological Research·Giuseppe IngrasciGil Yosipovitch

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