DOI: 10.1101/19010710Nov 2, 2019Paper

Per- and poly-fluoroalkyl substances and bone mineral density: results from the Bayesian weighted quantile sum regression

MedRxiv : the Preprint Server for Health Sciences
Elena ColicinoC. Gennings


Background: Per- and poly-fluoroalkyl substances (PFAS) are chemicals, detected in 95% of Americans, that induce osteotoxicity and modulate hormones thereby influencing bone health. Previous studies found associations between individual PFAS and bone mineral density but did not analyze their combined effects. Objective: To extend weighted quantile sum (WQS) regression to a Bayesian framework (BWQS) and determine the association between a mixture of serum PFAS and mineral density in lumbar spine, total and neck femur in 499 adults from the 2013-2014 National Health and Nutrition Examination Survey (NHANES). Methods: We used BWQS to assess the combined association of nine PFAS, as a mixture, with bone mineral density in adults. As secondary analyses, we focused on vulnerable populations (men over 50 years and postmenopausal women). Analyses were weighted according to NHANES weights and were adjusted for socio-demographic factors. Sensitivity analyses included bone mineral density associations with individual compounds and results from WQS regressions. Results: The mean age was 55 years old (Standard Error [SE]=1) with average spine, total and neck femur mineral densities of 1.01 (SE=0.01), 0.95 (SE=0.01), and 0.78 (SE=0.01) gm/cm...Continue Reading

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