Per- and polyfluoroalkyl substances (PFAS) in American Red Cross adult blood donors, 2000-2015

Environmental Research
Geary W OlsenCarol A Ley

Abstract

In 2015, thirteen per- and polyfluoroalkyl substances (PFAS), including perfluorohexanesulfonate (PFHxS), perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), perfluorononanoate (PFNA), and perfluorodecanoate (PFDA) were analyzed in human plasma that were collected from a total of 616 American Red Cross male and female blood donors (ages 20-69) at 6 regional blood collection centers. Plasma samples were analyzed using a validated solvent precipitation-isotope dilution direction-liquid chromatography tandem mass spectrometry method. The data were analyzed in conjunction with prior cross-sectional investigations [2000-2001 (n =645), 2006 (n =600), and 2010 (n =600)] to determine PFAS trends. Age- and sex-adjusted geometric mean serum (2000-2001) and plasma (2006, 2010, 2015) concentrations (ng/mL) were, respectively: PFHxS (2.3, 1.5, 1.3, 0.9); PFOS (35.1, 14.5, 8.4, 4.3); PFOA (4.7, 3.4, 2.4, 1.1); PFNA (0.6, 1.0, 0.8, 0.4); and PFDA (0.2, 0.3, 0.3, 0.1). The percentage decline in these geometric mean concentrations from 2000-2001 to 2015 were: PFHxS (61%); PFOS (88%); PFOA (77%); PFNA (33%); and PFDA (50%). The results indicate a continued decline of PFHxS, PFOS, and PFOA concentrations in American Red Cross blood donors...Continue Reading

Citations

Feb 21, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Matteo ConvertinoThomas R J Evans
Nov 17, 2017·Archives of Toxicology·Sook-Jin KimHea-Young Cho
Oct 10, 2019·Environmental Health Perspectives·Herbert P SusmannRuthann A Rudel
Nov 30, 2019·Journal of Analytical Toxicology·M Abdul MottalebAndrew J Morris
Jan 12, 2020·Transfusion Medicine·Maria AverinaBjørn Bolann
Sep 8, 2020·Environmental Science and Pollution Research International·Aasim M AliRoland Kallenborn
Sep 24, 2020·Environmental Health Perspectives·Kate M AnnunziatoAlicia R Timme-Laragy
Mar 8, 2020·International Journal of Environmental Research and Public Health·Alexis M TemkinLisa M Kamendulis
May 12, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Karen ChiuWenyan Mei
Feb 26, 2019·Soft Matter·Benjamin ViadaLidia M Yudi
Sep 9, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Carrie A McDonoughJamie C DeWitt
Sep 30, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marisa PfohlAngela L Slitt
Aug 25, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yiren YueYeonhwa Park
Jan 24, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marisa PfohlAngela L Slitt
Mar 9, 2021·Comprehensive Reviews in Food Science and Food Safety·Gregory GlennLauren Olson
Apr 12, 2021·Environmental Science and Pollution Research International·Vivian BergTherese Haugdahl Nøst
May 11, 2021·Journal of Analytical Methods in Chemistry·Thi Vi PhungHong Anh Duong
May 25, 2021·Environmental Science & Technology·Carrie A McDonoughChristopher P Higgins
Jun 3, 2021·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Teerapong LertassavakornJutamaad Satayavivad
Jul 10, 2021·Analytical and Bioanalytical Chemistry·Boris BugselChristian Zwiener

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.