Perampanel Confirms to Be Effective and Well-Tolerated as an Add-On Treatment in Patients With Brain Tumor-Related Epilepsy (PERADET Study)

Frontiers in Neurology
Antonietta CoppolaMarta Maschio

Abstract

Background: Epilepsy is one of the most common symptoms of brain tumors. It is often drug resistant and generally worsen patients' quality of life (QoL). Brain tumors release glutamate among other mediators, contributing to seizures onset, and this is accompanied by an increased AMPA receptors' expression on neuronal cells' membrane. Perampanel (PER) is a relatively new antiseizure medication (ASM) that acts as a selective non-competitive AMPA receptors' antagonist. Given its mechanism of action, we aimed to evaluate through a prospective, observational study, the efficacy and safety of PER as an add-on treatment in patients with brain tumor-related epilepsy (BTRE). The study was called PERADET. Methods: Thirty-six adult patients (intention to treat population-ITT) affected by BTRE, with uncontrolled focal-onset seizures treated with 1-3 ASMs were recruited from four Italian epilepsy centers. Perampanel was added-on, titrated from 2 mg/day up to a maximum of 12 mg/day. Tumor history and therapy, type, and seizures frequency, previous ASMs were collected at 6 and 12 months. A battery of QoL tests were administered at baseline, 6 and 12 months. The primary endpoint was to assess the efficacy of PER by calculating the percent chan...Continue Reading

References

Apr 12, 2002·Epilepsy Research·Salvatore StrianoLeonilda Bilo
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Apr 17, 2007·Lancet Neurology·Melanie S M van BreemenCharles J Vecht
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Dec 7, 2018·The International Journal of Neuroscience·Marta MaschioDiana Giannarelli
Aug 9, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Marta MaschioUNKNOWN Brain Tumor-related Epilepsy study group of Italian League Against Epilepsy (LICE)

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Citations

Nov 15, 2020·International Journal of Molecular Sciences·Daniel P Radin, Stella E Tsirka
Mar 12, 2021·Journal of the Neurological Sciences·Johanna HeugenhauserIris Unterberger
Apr 9, 2021·Frontiers in Oncology·Marco ZoccaratoGiuseppe Lombardi
Apr 30, 2021·Brain Tumor Research and Treatment·Jangsup MoonUNKNOWN KSNO Guideline Working Group
Jul 30, 2021·Therapeutics and Clinical Risk Management·Yotin ChinvarunTakamichi Yamamoto
Aug 25, 2021·Journal of Neurology·Vicente VillanuevaUNKNOWN PERMIT pooled analysis participants

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Methods Mentioned

BETA
BRTE

Software Mentioned

PER
SPSS
PERADET
QOLIE

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