Abstract
Cognitive symptoms are common after cancer, but poorly associated with neuropsychological results. We previously reported colorectal cancer (CRC) patients had more cognitive impairment than controls. Here, we explore relationships between cognitive symptoms and neuropsychological domains. Subjects with CRC (N = 362) and 72 healthy controls completed neuropsychological assessments and Functional Assessment of Cancer Therapy-Cognition (FACT-COG) at baseline (pre-chemotherapy) and 6, 12, and 24 months. Associations between neuropsychological and FACT-COG scores were explored: perceived cognitive impairment (PCI), perceived cognitive ability (PCA), impact of PCI on quality of life (CogQOL). Of 362 CRC subjects, 289 had loco-regional disease and 173 received chemotherapy (CTh+). At baseline, groups did not differ on total FACT-COG, PCI, or PCA scores. All scores, except PCA, were worse at 6 months in CTh+. CRC patients not receiving chemotherapy did not differ from controls on FACT-COG domains. PCA associated weakly (r = 0.28-0.34) with attention/executive function, visual memory, and global deficit score. There was no association between PCI and neuropsychological domains. Fatigue, anxiety/depression, and poorer quality of life wer...Continue Reading
References
Mar 3, 1993·Journal of the National Cancer Institute·N K AaronsonJ C de Haes
Feb 16, 2006·Psycho-oncology·Fiona P DownieIan F Tannock
Jun 9, 2009·Journal of Pain and Symptom Management·Jin-Shei LaiDavid Cella
Sep 18, 2009·Journal of Cancer Survivorship : Research and Practice·Nelli BoykoffSaskia Karen Subramanian
Mar 1, 2011·The Lancet Oncology·Jeffrey S WefelSanne B Schagen
May 24, 2011·Seminars in Oncology·Michelle C JanelsinsGary R Morrow
Jun 5, 2012·Cancer Treatment Reviews·Amanda D HutchinsonCarlene Wilson
Apr 23, 2013·Journal of the National Cancer Institute·Patricia A GanzThomas R Belin
Apr 5, 2014·Psycho-oncology·Jin-Shei LaiDavid Cella
Sep 13, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J VardyI F Tannock
Sep 23, 2014·Journal of Pain and Symptom Management·Diane Von Ah, Eileen F Tallman
Nov 4, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Janette L VardyIan F Tannock
Jul 23, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J L VardyI F Tannock
Jul 23, 2016·Cancer·Jeanne S MandelblattClaudine Isaacs
Citations
Jul 18, 2019·Journal of Cancer Survivorship : Research and Practice·Chelsea NicolMark B Pinkham
Oct 17, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M LangeH Castel
Mar 7, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patricia A Ganz, Kathleen Van Dyk
Mar 11, 2020·Brain and Behavior·Bénédicte GiffardMarie Lange
Nov 17, 2017·Psycho-oncology·Janette L Vardy, Haryana M Dhillon
Jul 1, 2020·Psycho-oncology·Chia Jie TanAlexandre Chan
Jul 16, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Shannon L GutenkunstMelanie L Bell
Feb 6, 2020·Psycho-oncology·Hee-Ju KimIvo Abraham
Jun 30, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Nadia MiladiBruno Gagnon
Mar 18, 2021·Journal of Cancer Survivorship : Research and Practice·Simone OerlemansLonneke V van de Poll-Franse
May 12, 2021·Journal of Cancer Survivorship : Research and Practice·Jennifer N VegaPaul A Newhouse
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M LangeH Castel
Sep 2, 2021·EClinicalMedicine·Laura TackPhilip R Debruyne
Jul 14, 2021·Journal of the National Cancer Institute·Janette L Vardy, Joanna Fardell