Perceived cognitive impairment in people with colorectal cancer who do and do not receive chemotherapy

Journal of Cancer Survivorship : Research and Practice
Haryana M DhillonJanette L Vardy

Abstract

Cognitive symptoms are common after cancer, but poorly associated with neuropsychological results. We previously reported colorectal cancer (CRC) patients had more cognitive impairment than controls. Here, we explore relationships between cognitive symptoms and neuropsychological domains. Subjects with CRC (N = 362) and 72 healthy controls completed neuropsychological assessments and Functional Assessment of Cancer Therapy-Cognition (FACT-COG) at baseline (pre-chemotherapy) and 6, 12, and 24 months. Associations between neuropsychological and FACT-COG scores were explored: perceived cognitive impairment (PCI), perceived cognitive ability (PCA), impact of PCI on quality of life (CogQOL). Of 362 CRC subjects, 289 had loco-regional disease and 173 received chemotherapy (CTh+). At baseline, groups did not differ on total FACT-COG, PCI, or PCA scores. All scores, except PCA, were worse at 6 months in CTh+. CRC patients not receiving chemotherapy did not differ from controls on FACT-COG domains. PCA associated weakly (r = 0.28-0.34) with attention/executive function, visual memory, and global deficit score. There was no association between PCI and neuropsychological domains. Fatigue, anxiety/depression, and poorer quality of life wer...Continue Reading

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Citations

Jul 18, 2019·Journal of Cancer Survivorship : Research and Practice·Chelsea NicolMark B Pinkham
Oct 17, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M LangeH Castel
Mar 7, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patricia A Ganz, Kathleen Van Dyk
Mar 11, 2020·Brain and Behavior·Bénédicte GiffardMarie Lange
Nov 17, 2017·Psycho-oncology·Janette L Vardy, Haryana M Dhillon
Jul 16, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Shannon L GutenkunstMelanie L Bell
Jun 30, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Nadia MiladiBruno Gagnon
Mar 18, 2021·Journal of Cancer Survivorship : Research and Practice·Simone OerlemansLonneke V van de Poll-Franse
May 12, 2021·Journal of Cancer Survivorship : Research and Practice·Jennifer N VegaPaul A Newhouse
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M LangeH Castel
Jul 14, 2021·Journal of the National Cancer Institute·Janette L Vardy, Joanna Fardell

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