Perceived discrimination is associated with the inflammatory response to acute laboratory stress in women at risk for cardiovascular disease

Brain, Behavior, and Immunity
Karen L SabanLinda Witek Janusek

Abstract

Cardiovascular disease (CVD) is the leading cause of death in the United States and exacts a disproportionate toll on minorities. Growing evidence demonstrates that perceived discrimination is a significant contributing factor to psychological distress, chronic low-grade inflammation, and cardiovascular health. However, little is known regarding the extent to which perceived discrimination contributes to the inflammatory response to acute stress. Therefore, the purpose of this study was to examine the influence of perceived discrimination on the inflammatory response to a laboratory acute stress paradigm in women at risk for CVD. A cross-sectional sample of 99 postmenopausal women (50 African American and 49 non-Hispanic White) (mean age 60.2 years) with at least two risk factors for CVD underwent the Trier Social Stress Test (TSST). Subjects completed the Detroit Area Study Discrimination Scale (DAS-DS) Everyday Discrimination subscale and provided blood and saliva samples prior to the TSST and every 15 min up to 90 min post-TSST to measure a pro-inflammatory cytokine, interleukin-6 (IL-6). Perceived discrimination was significantly associated with the salivary IL-6 response to the TSST (b = 0.49, SE = 0.13, p = <0.001) contro...Continue Reading

Associated Clinical Trials

Citations

Oct 10, 2018·Psychosomatic Medicine·Diana A ChirinosChristopher Fagundes
Jul 21, 2020·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Michelle I CardelMatthew J Gurka
Jul 25, 2020·The Journal of Clinical Endocrinology and Metabolism·Anthony S ZannasDavid R Rubinow
Nov 22, 2019·Frontiers in Molecular Biosciences·Kuldeep DhamaSunil Kumar Joshi
Feb 6, 2020·Journal of Racial and Ethnic Health Disparities·Dina HuangQuynh C Nguyen
Nov 30, 2018·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Karen L SabanLinda Janusek
Apr 1, 2020·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Samantha G BromfieldTené T Lewis
May 7, 2020·Brain, Behavior, and Immunity·Yvette Z SzaboJennifer E Graham-Engeland
Jul 21, 2020·Brain, Behavior, and Immunity·Adolfo G CuevasDavid R Williams
Mar 25, 2021·Stress : the International Journal on the Biology of Stress·Danica C Slavish, Yvette Z Szabo
Mar 18, 2021·Complementary Therapies in Medicine·Karen L SabanLinda Witek Janusek

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.