Perceived imbalance and risk of Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Xiang GaoAlberto Ascherio

Abstract

We prospectively examined associations between perceived imbalance and Parkinson's disease (PD) risk in the Health Professional Follow-up Study (HPFS), and Nurses' Health Study (NHS). We included 39,087 men and 82,299 women free of PD at baseline (1990) in the current analyses. We documented 449 incident PD cases during 12 years follow-up. Subjects who reported difficulty with balance before 1990 (baseline) were 1.8 more times likely to develop PD, relative to those who reported no balance difficulty (pooled multivariate RR = 1.8; 95% CI: 1.3, 2.5; P < 0.0001). When we further examined associations between perceived imbalance at baseline and PD onset during different time periods, we found a significant elevation of PD risk only during the first 4 years of follow-up. This result suggests that the imbalance may in some cases be an early sign of PD, and may represent the onset of motor symptoms although they have not been clinically recognized.

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Citations

Jul 2, 2011·American Journal of Epidemiology·Xiang GaoAlberto Ascherio
Dec 17, 2008·BMJ : British Medical Journal·Kathrine RugbjergJørgen H Olsen
Oct 27, 2014·European Journal of Applied Physiology·Denise McGrathBrian Caulfield
Aug 3, 2016·Clinical Medicine : Journal of the Royal College of Physicians of London·Anna SauerbierK Ray Chaudhuri
Apr 30, 2020·Neurology·Alejandra Camacho-SotoBrad A Racette
Aug 26, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Xiang GaoAlberto Ascherio
Oct 17, 2012·Annals of Neurology·Alastair J NoyceAnette Schrag
Mar 10, 2020·Parkinson's Disease·Irene M FaustSusan Searles Nielsen
Jun 18, 2011·Journal of the Neurological Sciences·Eduardo Tolosa, Claustre Pont-Sunyer

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