Perceived Stress is Associated with Accelerated Monocyte/Macrophage Aging Trajectories in Clinically Normal Adults

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Kaitlin B CasalettoJoel H Kramer

Abstract

Chronic stress is associated with poorer age-related cognition, but the mechanisms of this relationship are not well understood. Aging increases expression of activated macrophages, leading to exacerbated immune responses to stressors. We examined the impact of stress and aging on macrophage-related inflammation and cognition in clinically normal adults. Three hundred eighty clinically normal adults were followed longitudinally (age M = 73 years; visit range: 1-8; M = 2.5 visits). Participants completed the Perceived Stress Scale, a neuropsychological battery, and blood draws. Plasma was analyzed for cytokines related to macrophage function (interleukin 6, tumor necrosis factor alpha, macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta). Linear mixed-effects examined the effects of age, baseline stress, and their interaction predicting macrophage cytokines, adjusting for sex, education, and depressive symptoms. Latent growth curve models assessed the mediating role of macrophage cytokines in the relationship between age and cognition in high or low stress. Baseline perceived stress interacted with age to predict macrophage cytokines longitudinally. Specifically, high-stress adults demonstrated accele...Continue Reading

Citations

Sep 25, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Cutter A LindberghJoel H Kramer
Jun 11, 2019·Current Opinion in Behavioral Sciences·Rebecca G Reed
May 23, 2021·Mechanisms of Ageing and Development·Jéssica CostaAna L Cardoso
Jun 11, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Cutter A LindberghUNKNOWN Hillblom Aging Network
Jan 8, 2022·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Crystle-Joie AgbayaniMichelle A Fortier

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