Percentage of Memory B Lymphocytes and Regulatory T Lymphocytes in Peripheral Blood are Low but Not Predictive of Therapy outcomes in Newly Diagnosed Adult Patients with Primary Immune Thrombocytopenia

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion
Mustafa Yilmaz, Semiha Ayhan

Abstract

Although changes in the number and function of regulatory T lymphocytes have been reported in primary immune thrombocytopenia (ITP), no study has investigated whether quantification of these cell types in peripheral blood could be used as early predictive marker of treatment outcome. And, it is not clear whether any change occurs in peripheral blood memory B lymphocyte levels in ITP. Hence, the aim of this study was to investigate the percentage of regulatory T lymphocytes and memory B lymphocytes in peripheral blood of ITP patients compared to controls, and also examine whether these levels have any significant predictive value for therapy outcome. A total of 20 newly diagnosed, untreated patients with ITP and 20 healthy controls were included. Flow cytometric analyses of lymphocyte subtypes in the peripheral blood were performed in specimens obtained from patients at the time of diagnosis and one month after the therapy initiation. First line corticosteroid (1 mg/kg/day methylprednisolone) therapy or splenectomy as second line treatment was performed, and patients were followed up for 3 years. Percentage of regulatory T lymphocytes (0.25 ± 0.17% vs. 1.14 ± 0.77%, P < 0.0001, n = 20) and percentage of memory B lymphocytes (1.5...Continue Reading

References

Oct 28, 2006·Thrombosis Research·Miho SakakuraHiroshi Shiku
Mar 5, 2008·Clinical & Developmental Immunology·Nathalie CoolsZwi N Berneman
Apr 9, 2008·European Journal of Immunology·Cristina M CostantinoDavid A Hafler
Nov 4, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Lorena Martinez-GamboaThomas Dörner
Oct 13, 2009·Arthritis Research & Therapy·Maria J Leandro
Oct 24, 2009·Arthritis Research & Therapy·Thomas DörnerPeter E Lipsky

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