Percentile categorization of QT interval as an approach for identifying adult patients at risk for cardiovascular death

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Reza MohebiVictor Froelicher

Abstract

The results from studies of the association of QT prolongation with cardiovascular death (CVD) have been inconsistent. The purpose of this study was to compare the major correction formulas to percentile values of QT for heart rate ranges as to their ability to remove the relationship of QT to heart rate and to predict CVD. Participants were 16,531 veterans who had an initial ECG at the Veterans Affairs Medical Center, Palo Alto, between March 31, 1987, and December 20, 1999, and were followed for CVD. The 4 major correction formulas (Bazett, Fridericia, Framingham, and Hodges) were used to correct QT interval. In addition, the percentiles for heart rate ranges as proposed by Schwartz were calculated. During median follow-up of 17.8 years, 455 CVD events occurred. When compared to the other equations, QTc Bazett had the greatest dependence on heart rate (R2 = 0.18). The hazard ratio (95% confidence interval) for CVD was 2.08 (1.28-3.9) for the 98th percentile of QT interval by heart rate ranges, 2.05 (1.27-3.33) for QTc Bazett, 1.39 (0.44-4.34) for QTc Fridericia, 1.05 (0.26-4.24) for QTc Hodges, and 1.12 (0.28-4.52) for QTc Framingham. The hazard ratio of QTc Bazett was significantly higher than the other formulas except for t...Continue Reading

References

Sep 15, 1992·The American Journal of Cardiology·A SagieD Levy
Jan 1, 1985·The Journal of Emergency Medicine·J L Scott, R M Walls
Feb 1, 1996·British Journal of Clinical Pharmacology·M ThomasE Fletcher
Jun 12, 1998·The New England Journal of Medicine·P J SchwartzP Salice
Nov 24, 1999·Lancet·S Viskin
Feb 19, 2004·The American Journal of Cardiology·Bimal R ShahVictor F Froelicher
Nov 10, 2004·Journal of Electrocardiology·Shen LuoPeter W Macfarlane
Apr 22, 2005·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Abdullah DoganMustafa Ozturk
Jun 1, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Sami ViskinDavid Zeltser
Jan 18, 2006·Journal of the American College of Cardiology·Sabine M J M StrausJacqueline C M Witteman
Sep 2, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Julia H IndikRaymond L Woosley
Feb 6, 2007·Journal of Electrocardiology·Jay W MasonBoaz Mendzelevski
Feb 27, 2010·Journal of the American College of Cardiology·Barbara J DrewUNKNOWN American College of Cardiology Foundation
Mar 18, 2010·Journal of Cardiovascular Electrophysiology·John ChiladakisDimitrios Alexopoulos
Feb 25, 2011·European Heart Journal·Jonathan N JohnsonMichael J Ackerman
Jun 24, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Kristina H HaugaaMichael J Ackerman
Dec 15, 2015·The Journal of Physiology·Dan M Roden
Jun 19, 2016·Journal of the American Heart Association·Bert VandenberkRik Willems

❮ Previous
Next ❯

Citations

Oct 17, 2017·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·David HadleyVictor F Froelicher
Jun 27, 2019·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·David HadleyVictor F Froelicher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.