Perception matters: Stressful life events increase breast cancer risk

Journal of Psychosomatic Research
Avital FischerH Anton-Culver

Abstract

The relationship between psychological stress and breast cancer risk is unclear. The present study sought to understand how stressfulness appraisal of salient Life Events (LEs) influences breast cancer risk. A case-control design was used and included 664 female cases identified through the Cancer Surveillance Program of Orange County, CA and 203 female population-based controls. A LE questionnaire determined if events occurred prior to breast cancer diagnosis and if these events were considered to be stressful or not. Multivariate unconditional logistic regression was used to calculate ORs while adjusting for known breast cancer covariates. Cumulative adverse LEs perceived as stressful were associated with increased breast cancer risk in a dose response fashion (OR = 1.63, 95% CI = 1.00-2.66, Ptrend = 0.045). Conversely, events perceived as non-stressful did not have a significant impact on breast cancer risk. Previous personal illness was directly related to increased breast cancer risk, whether perceived as stressful (OR = 2.84, 95% CI = 1.96-4.11) or non-stressful (OR = 3.47, 95% CI = 1.34-8.94). Abortion and relocation were observed to have a protective effect on breast cancer risk only when reported as stressful (OR = 0.5...Continue Reading

Citations

Dec 10, 2019·Oxidative Medicine and Cellular Longevity·Joanna KrukMagdalena Gronostaj
Mar 7, 2021·International Journal of Environmental Research and Public Health·Deborah J BowenDavid R Williams
Jul 5, 2021·Public Health·M-Ch Virago

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