Perchlorate, iodine supplements, iodized salt and breast milk iodine content

The Science of the Total Environment
Andrea B KirkPurnendu K Dasgupta

Abstract

This study was undertaken to determine if increasing maternal iodine intake through single dose tablets will decrease breast milk concentrations of the iodine-uptake inhibitor, perchlorate, through competitive inhibition. We also sought to determine if the timing of supplementation influences the fraction of iodine excreted in milk versus urine and to compare the effectiveness of iodized salt as a means of providing iodine to breastfed infants. Thirteen women who did not use supplements, seven of whom used iodized salt and six of whom used non-iodized salt, submitted four milk samples and a 24-h urine collection daily for three days. Women repeated the sampling protocol for three more days during which ~150μg of iodine were taken in the evening and again for three days with morning supplementation. Samples were analyzed using isotope-dilution inductively-coupled plasma-mass spectrometry for iodine and isotope-dilution ion chromatography-tandem mass spectrometry for perchlorate. No statistically significant differences were observed in milk iodine or perchlorate concentrations during the two treatment periods. Estimated perchlorate intake was above the U.S. National Academy of Sciences suggested reference dose for most infants. ...Continue Reading

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Citations

Oct 12, 2012·Thyroid : Official Journal of the American Thyroid Association·Angela M LeungElizabeth N Pearce
Jul 26, 2012·Thyroid : Official Journal of the American Thyroid Association·Angela M LeungElizabeth N Pearce
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