Percutaneous absorption of 2,4-dichlorophenoxyacetic acid from soil with respect to soil load and skin contact time: in vivo absorption in rhesus monkey and in vitro absorption in human skin

Journal of Toxicology and Environmental Health
R C WesterK C Huang

Abstract

The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), used for control of weeds in agriculture, forestry, and rights of way, can accumulate as a residual chemical in soil. The objective was to determine percutaneous absorption of 2,4-D from soil, with emphasis on soil load and skin contact time. With control acetone vehicle, in vivo absorption of 2,4-D in the rhesus monkey was 8.6 +/- 2.1% of the dose, which compared closely to published human absorption of 6.0 +/- 2.4%. Percutaneous absorption from soil loads of 1 and 40 mg/cm2 were 9.8 +/- 4.0 and 15.9 +/- 4.7%, respectively, values similar to acetone vehicle. In vitro absorption in human skin calculated from skin contact accumulation over 24 h was 1.8 +/- 1.7, 1.7 +/- 1.3, and 1.4 +/- 1.2% for soil loads of 5, 10, and 40 mg/cm2, respectively. Thus, soil load did not affect 24-h percutaneous absorption. Current Environmental Protection Agency (EPA) recommended calculated reductions due to soil load are not supported by these results with 2,4-D. Percutaneous absorption of 2,4-D from acetone vehicle for 8 h dosing period was 3.2 +/- 1.0%, one-third the value of 8.6 +/- 2.1% over 24 h. With soil vehicle, absorption for 8 h was only 0.03 +/- 0.02% for 40 mg/cm2 soil load and 0.05...Continue Reading

Citations

Jun 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R P Moody, B Nadeau
Oct 3, 2008·Journal of Exposure Science & Environmental Epidemiology·Elizabeth W SpaltAnnette L Bunge
Jan 28, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·B Godin, E Touitou
Oct 9, 1999·Journal of Pharmaceutical Sciences·B C Finnin, T M Morgan
Sep 6, 2001·Journal of Pharmaceutical Sciences·K S WarnerW I Higuchi
Oct 31, 2006·Integrated Environmental Assessment and Management·LaDonna M ChoateDonald L Macalady
Oct 28, 2014·Journal of Applied Toxicology : JAT·Eui Chang Jung, Howard I Maibach
Aug 6, 2009·International Journal of Toxicology·Lillian C BeckerF Alan Andersen
Sep 11, 2014·Reviews on Environmental Health·Rosa Marie AndersenHoward I Maibach

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