Percutaneous absorption of 5 glycol ethers through human skin in vitro

Toxicology in Vitro : an International Journal Published in Association with BIBRA
M VenierN Renzi

Abstract

Absorption across full thickness human skin was evaluated in vitro for five selected glycol ethers. Skin membranes were settled on static diffusion cells and both neat and 50% water diluted glycol ethers were applied on the donor chamber for 8 h. The amount of glycol ethers permeated into the receptor fluid was measured by gas chromatograph equipped with flame ionization detector (GC-FID). For neat solvents, permeation coefficient Kp ranged from 0.06 to 0.83 cm h(-1) 10(-3) respectively for DEGBEA and EGMEA while for 50% v/v diluted glycol ethers it varied from 0.08 to 1.81 cm h(-1) 10(-3) respectively for DPGME and EGMEA. These experiments show a statistically significant (Student's t-test, P <0.05) increase in permeation coefficients from neat to 50% water diluted glycol ethers and the same trend can be observed in fluxes and lag times. Only DPGME show an opposite behaviour. These results confirm the good ability of these solvents of permeating the skin and show that they could represent a risk for their potential dermal absorption both for workers and for occasional exposures, since the average lag time is 1.57 h.

References

Feb 1, 1992·British Journal of Industrial Medicine·F LareseR De Zotti
Nov 1, 1991·British Journal of Industrial Medicine·G Johanson, A Boman
Jan 1, 1989·International Archives of Occupational and Environmental Health·D GroesenekenE Van Vlem
Jan 1, 1988·American Journal of Industrial Medicine·P GrandjeanW Penning
Oct 1, 1988·Toxicology Letters·G Johanson
Jan 1, 1988·The American Journal of Medicine·D JacobsenK E McMartin
Apr 1, 1988·Scandinavian Journal of Work, Environment & Health·G JohansonB Dynésius
Jan 1, 1987·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·F G BartnikK Kunstler
Jan 1, 1987·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J MerkleR Jäckh
Aug 1, 1984·Environmental Health Perspectives·P H DugardR C Scott
Aug 1, 1984·Environmental Health Perspectives·P M FosterT J Gray
Oct 1, 1995·Occupational Medicine·J LaitinenH Savolainen
Sep 1, 1996·Occupational and Environmental Medicine·J LaitinenH Savolainen
Oct 29, 1999·International Archives of Occupational and Environmental Health·F Larese FilonE Reisenhofer
Jun 14, 2000·Critical Reviews in Toxicology·G Johanson
Jun 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J N Lawrence

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Citations

May 15, 2012·Advanced Drug Delivery Reviews·Longjian ChenGuoping Lian
Jul 7, 2007·Cutaneous and Ocular Toxicology·H Frederick FraschJames N McDougal
Aug 3, 2006·Journal of Pharmaceutical Sciences·Ana M Barbero, H Frederick Frasch
Feb 15, 2012·International Journal of Pharmaceutics·Annette L BungeJean Paul Payan
Apr 28, 2009·Regulatory Toxicology and Pharmacology : RTP·Harrie E BuistJohannes J M van de Sandt
Mar 27, 2007·Toxicology Letters·Francesca LareseNadia Renzi
Jul 11, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·G AdamiE Reisenhofer
Dec 25, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Gintautas KorinthHans Drexler
Jul 21, 2016·Journal of Exposure Science & Environmental Epidemiology·Ji-Eun SeoBae-Hwan Kim
Apr 7, 2006·International Journal of Toxicology·Michael KoontzTipton Tyler
Nov 6, 2009·PloS One·Angelo QuarantaClaudio Lippe

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