PMID: 6975603Jan 1, 1981Paper

Percutaneous absorption of griseofulvin and proquazone in the rat and in isolated human skin

Archives of Dermatological Research
J M FranzA Schweitzer

Abstract

Ointments containing griseofulvin and proquazone, respectively, were made up of monoglycerides of medium chain length and an aprotic solvent, glycerinformal. The ointments were applied topically on the back of bile cannulated rats. The total amount absorbed percutaneously and the permeability constants of both drugs were considerably higher for the ointments than for simple solutions of the drugs without monoglycerides. Distribution of the labeled drugs in rat skin has been demonstrated by microautoradiography. Concentrations of the drugs in the different layers of human skin together with the medium flow rates have been determined 16 h after administration of the ointments onto isolated human skin. Monoglycerides of medium chain length enhance significantly the permeability of the stratum corneum for solutes.

References

Oct 1, 1975·Archives of Dermatology·W L EpsteinS Riegelman
Dec 1, 1969·The Journal of Clinical Investigation·H J Weis, J M Dietschy
Nov 1, 1965·Archives of Dermatology·D D Munro, R B Stoughton

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Citations

Mar 17, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Barbara Gabriele Auner, Claudia Valenta
Oct 1, 1990·The Journal of Pharmacy and Pharmacology·M E NimniR A Oakes
Jul 3, 2007·Biological & Pharmaceutical Bulletin·Takayuki FuruishiKazuo Tomono
Oct 1, 1991·Journal of the American Academy of Dermatology·L F MontesM E Nimni
Dec 1, 1999·The Journal of Pharmacy and Pharmacology·L Peng, M E Nimni

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