Percutaneous and surgical treatment of aortic stenosis

Expert Review of Cardiovascular Therapy
Bruce W Andrus, Daniel J O'Rourke

Abstract

Aortic stenosis due to calcific degeneration is the most common valvular disorder among the elderly. With the growing elderly population, the prevalence of this disease will continue to increase. Based on converging lines of evidence linking calcific aortic stenosis with atherosclerosis, there has been interest in drug therapy to slow the progression of aortic stenosis. Unfortunately, recently completed prospective trials have been disappointing. Mechanical measures remain the principal form of therapy. Among percutaneous techniques, aortic valvuloplasty provides only transient and modest benefit at a significant risk of stroke and vascular injury. However, aortic valvuloplasty can play a useful role in stabilizing patients who require additional attention prior to definitive surgery. Building on this foundation, a bold new technique of percutaneously implanting a balloon-mounted valve has been developed. Although promising, there have been relatively few patients treated in this fashion (at a single center) and with only limited follow-up. Surgical treatment, specifically valve replacement, is still the definitive treatment of choice for patients with symptomatic aortic stenosis. Surgeons and patients must choose between a var...Continue Reading

References

May 13, 1999·The Annals of Thoracic Surgery·H E MächlerB Rigler
Sep 21, 2000·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·B KassaïJ P Boissel
Jan 10, 2002·The Journal of Thoracic and Cardiovascular Surgery·Kelvin H H LimAlan J Bryan
Mar 20, 2002·The Annals of Thoracic Surgery·Gideon CohenBernard S Goldman
May 22, 2002·Journal of the American College of Cardiology·Philipp BonhoefferDaniel Sidi
Oct 3, 2002·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·Paolo MasielloGiuseppe Di Benedetto
Oct 16, 2002·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·Peter KleineAnton Moritz
Mar 26, 2003·Journal of the American College of Cardiology·Shahbudin H Rahimtoola
Sep 13, 2003·Circulation·Bruce W AndrusRobert T Palac
Oct 1, 1961·Annals of Surgery·A STARR, M L EDWARDS
Nov 25, 2003·Journal of Interventional Cardiology·Hélène EltchaninoffAlain Cribier
Apr 7, 2004·Circulation·Alec Vahanian, Igor F Palacios
May 18, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·N AlphonsoD Anderson
Aug 5, 2004·The International Journal of Artificial Organs·Y S MorsiF L Rosenfeldt
Sep 9, 2004·The Journal of Thoracic and Cardiovascular Surgery·Tomaso BottioGino Gerosa
Oct 1, 2004·The Journal of Thoracic and Cardiovascular Surgery·Elena Rabkin-AikawaFrederick J Schoen
May 4, 2005·The Journal of Thoracic and Cardiovascular Surgery·F DagenaisP Mathieu
May 21, 2005·Cardiology in the Young·Riccardo Pietrabissa, Vincenzo Stefano Luisi
Jun 10, 2005·The New England Journal of Medicine·S Joanna CowellUNKNOWN Scottish Aortic Stenosis and Lipid Lowering Trial, Impact on Regression (SALTIRE) Investigators

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