Percutaneous approaches to mitral regurgitation.

Current Treatment Options in Cardiovascular Medicine
Faisal Alqoofi, Ted Feldman

Abstract

Percutaneous therapy for mitral repair has emerged over the past several years as an investigational option for treating mitral regurgitation (MR). A variety of novel methods to treat MR using a percutaneous route have been developed. Most of these approaches are modifications of surgical techniques, some established and some obscure. The basic surgical approaches to mitral repair are annuloplasty and leaflet repair. Catheter-based devices mimic or approximate these surgical approaches. MR as a disease process is heterogeneous, and different therapeutic approaches are needed for different etiologies of MR and morphologies of the mitral apparatus. Primary leaflet diseases are mitral prolapse and fibroelastic deficiency. Secondary, or functional, MR exists when the leaflets are normal. Functional ischemic MR and functional MR related to heart failure occur in different populations and historically have had different responses to surgical therapy. Leaflet repair using a percutaneous clip has been accomplished for patients with mitral valve prolapse and also some patients with functional MR. Indirect annuloplasty via the coronary sinus has shown promising early human trial results in patients with functional MR. Direct annuloplasty...Continue Reading

References

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May 26, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ted Feldman
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Jun 19, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Wes R PedersenTed Feldman

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Citations

Jun 15, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Eduardo Alegria-BarreroOlaf W Franzen
May 4, 2010·Mayo Clinic Proceedings·Kameswari MagantiRobert O Bonow
Jul 1, 2010·Journal of the Saudi Heart Association·R S Schofield, P M Schofield
Jan 18, 2017·Echo Research and Practice·Malgorzata WamilJames Newton

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