Percutaneous catheter drainage combined with peritoneal dialysis for treating acute severe pancreatitis: a single-center prospective study

Minerva chirurgica
Wenhao ZhangShoutao Yuan

Abstract

To investigate the efficacy of percutaneous catheter drainage (PCD) and peritoneal dialysis (PD) in the treatment of severe acute pancreatitis (SAP) and its underlying mechanism. Totally 64 SAP patients were included in our study and randomly assigned into PCD+PD group (the combination group, N.=32) and convention group (N.=32). SAP patients in the combination group were treated with percutaneous catheter drainage combined with peritoneal dialysis, while those in the convention group were treated with conventional method. The treatment efficacy of both methods were evaluated by comparing levels of plasma inflammatory cytokines (IL-6, IL-8, TNF-α, C-reactive protein, procalcitonin and leukocyte count), relative indexes of important organs (aspartate aminotransferase, alanine aminotransferase, creatinine and urea nitrogen) and other clinical data (amelioration time of abdominal pain and abdominal distension, Balthazar CT scores, acute physiology and chronic health enquiry II score, length of hospital stay, complications and prognosis). The expression levels of inflammatory cytokines were significantly decreased in the combination group in a time-dependent manner in comparison with those of the convention group. In addition, the a...Continue Reading

References

Feb 1, 1990·Radiology·E J BalthazarJ H Ranson
Aug 23, 2000·Current Opinion in Obstetrics & Gynecology·K D Jones, C J Sutton
Dec 8, 2000·Clinical Techniques in Small Animal Practice·M A Labato
Mar 2, 2002·Fertility and Sterility·Ludovico MuziiPierluigi Benedetti Panici
Mar 6, 2003·Critical Care : the Official Journal of the Critical Care Forum·Canan BalcIBünyamin Kaptanoglu
Sep 26, 2003·American Journal of Reproductive Immunology : AJRI·Murat Berkkanoglu, Aydin Arici
Mar 29, 2005·American Journal of Surgery·Mark A Malangoni, Adam S Martin
Feb 24, 2006·Annals of Surgery·Austin L SpitzerHobart W Harris
May 19, 2006·The New England Journal of Medicine·David C Whitcomb
Sep 26, 2007·The Journal of Pathology·A VonlaufenJ L Frossard
Apr 11, 2008·Journal of Gastroenterology and Hepatology·Fred GorelickEdwin Thrower
Mar 20, 2008·World Journal of Gastroenterology : WJG·Kun JiangLei Wang
Sep 30, 2009·Journal of Gastroenterology·Xinbo AiSumio Watanabe
Apr 23, 2010·The New England Journal of Medicine·Hjalmar C van SantvoortUNKNOWN Dutch Pancreatitis Study Group
Dec 8, 2010·The British Journal of Surgery·M C van BaalUNKNOWN Dutch Pancreatitis Study Group
Apr 12, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Enver ZeremBahrija Haračić
Sep 13, 2012·Annals of Surgery·Raghavendra Yalakanti BabuRajinder Singh
Aug 15, 2013·Surgical Endoscopy·Marek WrońskiIreneusz W Krasnodębski

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