Percutaneous coronary intervention for chronic total occlusion in patients aged <75 years versus ≥75 years: a systematic review.

Journal of Community Hospital Internal Medicine Perspectives
Noman LateefMark Holmberg

Abstract

Objective: To examine the effect of age on procedural and clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) of chronic total occlusion (CTO) lesions. Methods: Literature search was conducted across PubMed, Google Scholar and Web of science, databases till March 2019. Results: Seven studies including 7671 patients with an overall follow-up period of 1.5 to 5 years were included in our review. A total of 6299/1372 patients were included in non-elderly and elderly groups, respectively, with mean age and 67%/61% male patients. CTO-PCI was similarly successful in younger and older patients (82.8%, n = 5070 vs. 78.1%, n = 1010). The incidence of short-term outcomes was low across the studies and comparable between the two groups (all-cause mortality: 0.4% younger vs. 0.85% elderly, cerebrovascular accidents: 0.3% vs. 0.4%, major adverse cardiovascular events (MACE): 1.53% vs. 3.72% and major bleeding: 0.57% vs. 2.18%). Long-term outcomes including all-cause mortality (8.89% vs. 29.5%), cardiac mortality (3.72% vs. 15%) and MACE (24.9% vs. 40%) occurred with a higher incidence in elderly patients. When results were segregated according to the success of CTO-PCI, reduced clinical events were noted with s...Continue Reading

References

Sep 16, 2010·Current Treatment Options in Cardiovascular Medicine·Samip VasaiwalaLaura Mauri
Mar 10, 2012·Journal of the American College of Cardiology·Paul FeferBradley H Strauss
Feb 26, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Loes P HoebersUNKNOWN Multinational CTO Registry
Mar 19, 2015·The American Journal of Cardiology·Georgios E ChristakopoulosEmmanouil S Brilakis
Nov 22, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Aurel TomaHeinz Joachim Buettner
Feb 7, 2018·The American Journal of the Medical Sciences·Hui-Ping ZhangJing-Hua Liu
Aug 11, 2018·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Stefan P SchumacherPaul Knaapen
Sep 17, 2018·JACC. Cardiovascular Interventions·Kambis MashayekhiHeinz Joachim Büttner
Jan 23, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Franz-Josef NeumannMichael O Zembala

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Citations

Feb 17, 2021·Journal of the American Geriatrics Society·Evangelia VemmouEmmanouil S Brilakis

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Methods Mentioned

BETA
coronary artery bypass
dissection

Software Mentioned

PRISMA
Google Scholar

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