Percutaneous coronary intervention results in acute increases in native and oxidized lipoprotein(a) in patients with acute coronary syndrome and stable coronary artery disease

Clinical Biochemistry
Jun-jun WangKe Li

Abstract

To investigate possible changes of native and oxidized lipoprotein(a) [ox-Lp(a)] levels after percutaneous coronary intervention (PCI). Lp(a), ox-Lp(a), and Lp(a) immune complexes (IC) and autoantibody levels were studied in 111 patients with acute coronary syndrome (ACS) and 68 patients with stable coronary artery disease (CAD) before and after PCI. Compared with pre-PCI, Lp(a), ox-Lp(a), and Lp(a)-IC levels acutely increased, while the autoantibody decreased in both the ACS and stable CAD patients. They all returned toward baseline by 1 to 2 days. The absolute change of ox-Lp(a) was found positively related with both the diameter of stenosis (R=0.273, P=0.004) and the number of vessel disease (R=0.312, P=0.001) in the ACS patients, while not in the stable CAD patients. PCI results in acute plasma increases of ox-Lp(a) and Lp(a). Ox-Lp(a) may be present in ruptured or permeable plaques and be released into the circulation by PCI.

References

Mar 1, 1991·The Journal of Clinical Investigation·T F ZioncheckR M Lawn
Aug 1, 1991·Annals of Internal Medicine·A M ScanuK Berg
Aug 1, 1989·Atherosclerosis·S MaedaM Kawade
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D P WadeR M Lawn
Jan 1, 1994·Chemistry and Physics of Lipids·M NaruszewiczeJ Davignon
Jan 1, 1994·Chemistry and Physics of Lipids·H F HoffA Yashiro
Nov 14, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·J J WangX D Yao
Jan 28, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·P HolvoetJ Vanhaecke
Aug 5, 1998·Kidney International·E A PodrezH F Hoff
May 23, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·P HolvoetF Van de Werf
Oct 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Kyoko NishiShinji Nagahiro
Dec 17, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Junjun WangSumei Wang
Feb 11, 2003·Journal of the American College of Cardiology·Sotirios TsimikasJoseph L Witztum
Aug 11, 2004·Clinical Biochemistry·Junjun WangXiaomei Feng
Jul 8, 2005·The New England Journal of Medicine·Sotirios TsimikasPeter B Berger
Nov 28, 2006·The American Journal of Cardiology·Sotirios Tsimikas
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos
Jun 24, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Junjun WangChunni Zhang
Aug 4, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jun-jun WangKe Li

❮ Previous
Next ❯

Citations

Nov 8, 2011·Journal of Atherosclerosis and Thrombosis·Jun-jun WangChun-ni Zhang
Dec 3, 2015·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Abhishek Biswas
May 17, 2011·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Constantine A Manthous
Mar 3, 2019·International Journal of Molecular Sciences·Zahra Solati, Amir Ravandi
May 27, 2020·Cardiology and Therapy·Keon Pearson, Fatima Rodriguez

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.