Percutaneous delivery of carbamazepine and selected N-alkyl and N-hydroxyalkyl analogues

International Journal of Pharmaceutics
L FourieJ Hadgraft

Abstract

Advantages associated with the transdermal delivery route are well documented, but in the past scientists have concentrated primarily on means of decreasing the barrier function of the skin for improved permeability. Pro-drugs, which possess more favourable physicochemical properties for improved transdermal permeability may have considerable potential. These have been considered in the past but recent information concerning structure activity relationships in dermal penetration has prompted increased interest. During this study, N-methyl (2), N-ethyl (3) and N-(2-hydroxyethyl) carbamazepine (4) analogues were synthesised for transdermal evaluation.

References

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Citations

Nov 17, 2006·Pharmaceutical Research·Kenneth B SloanJarkko Rautio
Jul 9, 2008·Drug Development and Industrial Pharmacy·Amjad QandilBassam Tashtoush
Feb 9, 2007·Journal of Pharmaceutical Sciences·Paola MinghettiAdamo Fini
Feb 3, 2006·The Journal of Pharmacy and Pharmacology·Gary P MossW John Pugh
May 8, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Abdelbaset A ElzagallaaiGideon Koren
Sep 11, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Rivka EfratDganit Danino

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