Percutaneous intervention in peripheral artery disease improves calf muscle phosphocreatine recovery kinetics: a pilot study.

Vascular Medicine
Amy M WestChristopher M Kramer

Abstract

We hypothesized that percutaneous intervention in the affected lower extremity artery would improve calf muscle perfusion and cellular metabolism in patients with claudication and peripheral artery disease (PAD) as measured by magnetic resonance imaging (MRI) and spectroscopy (MRS). Ten patients with symptomatic PAD (mean ± SD: age 57 ± 9 years; ankle-brachial index (ABI) 0.62 ± 0.17; seven males) were studied 2 months before and 10 months after lower extremity percutaneous intervention. Calf muscle phosphocreatine recovery time constant (PCr) in the revascularized leg was measured by (31)P MRS immediately after symptom-limited exercise on a 1.5-T scanner. Calf muscle perfusion was measured using first-pass gadolinium-enhanced MRI at peak exercise. A 6-minute walk and treadmill test were performed. The PCr recovery time constant improved significantly following intervention (91 ± 33 s to 52 ± 34 s, p < 0.003). Rest ABI also improved (0.62 ± 0.17 to 0.93 ± 0.25, p < 0.003). There was no difference in MRI-measured tissue perfusion or exercise parameters, although the study was underpowered for these endpoints. In conclusion, in this pilot study, successful large vessel percutaneous intervention in patients with symptomatic claudi...Continue Reading

References

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Citations

Jan 22, 2013·Current Cardiovascular Imaging Reports·Amy W Pollak, Christopher M Kramer
Mar 19, 2013·Current Cardiovascular Imaging Reports·David Lopez, Christopher M Kramer
Apr 14, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Joshua L HeusleinRichard J Price
Mar 1, 2012·Vascular Medicine·Reena L Pande
Apr 11, 2018·Vascular Medicine·Roshin C Mathew, Christopher M Kramer
Apr 8, 2017·Journal of Applied Physiology·J Carter LuckMatthew D Muller
Feb 12, 2020·Experimental Physiology·Jefferson C FrisbeeRobert W Wiseman
Sep 18, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Mary M McDermottRobert Sufit
Mar 30, 2017·Frontiers in Physiology·Victoria G RontoyanniCraig Porter
Jun 8, 2017·Experimental and Therapeutic Medicine·Peng ChenChengming Yang

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Methods Mentioned

BETA
electron microscopy
percutaneous transluminal angioplasty
coronary artery bypass

Software Mentioned

Argus
SPSS
PASW Statistics

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