Percutaneous penetration and pharmacodynamics: Wash-in and wash-off of sunscreen and insect repellent

The Journal of Dermatological Treatment
Jocelyn Rodriguez, Howard I Maibach

Abstract

Increased awareness of skin cancer and mosquito-transmitted diseases has increased use of insect repellents and sunscreens. The challenge in setting recommendations for use and reapplication, especially when used concomitantly, lies in finding the balance between applying a durable product effective in withstanding natural and physical factors such as water, sweat, temperature and abrasion, while limiting percutaneous absorption and decreasing risk of potential dermal and systemic toxicity. Inorganic sunscreens show no or little percutaneous absorption or toxic effects in comparison to organic sunscreens, which show varying levels of dermal penetration and cutaneous adverse effects. An alternative to N,N-diethyl-m-toluamide (DEET), the traditional gold standard compound in insect repellents, picaridin appears as efficacious, has lower risk of toxicity, and when used simultaneously with sunscreen may decrease percutaneous absorption of both compounds. Conversely, combined use of DEET and sunscreen results in significantly higher absorption of both compounds. It is important to increase consumer awareness of "washing in" of various compounds leading to increased risk of toxicity, as well as differences in reapplication need due t...Continue Reading

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Citations

Mar 16, 2017·Photochemistry and Photobiology·Gagan ChhabraNihal Ahmad
Nov 5, 2019·American Journal of Clinical Dermatology·Rebecca M LawHoward I Maibach

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