Percutaneous penetration of octyl salicylate from representative sunscreen formulations through human skin in vitro

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
K A WaltersS D Gettings

Abstract

The human skin penetration of [14C]octyl salicylate from two representative sunscreen vehicles was determined in vitro. 3H-sucrose was incorporated into all formulations and provided a marker for membrane integrity. When applied as a finite dose in an oil-in-water emulsion vehicle containing 5% (w/w) octyl salicylate, the average total absorption of 14C over 48 hr was 0.65+/-0.16% of the applied dose (representing a total amount permeated of 1.58+/-0.36 microg/cm2). When applied as an infinite dose in the oil-in-water emulsion vehicle the average total absorption of 14C over 48 hr was 0.47+/-0.22% of the applied dose (representing a total amount permeated of 27.54+/-13.91 microg/cm2). When applied as a finite dose in a representative hydroalcoholic formulation containing 5% (w/w) octyl salicylate, the average total absorption of 14C over 48 hr was 0.59+/-0.09% of the applied dose (representing a total amount permeated of 1.58+/-0.25 microg/cm2). When applied as an infinite dose in the hydroalcoholic formulation the average total absorption of 14C over 48 hr was 0.23+/-0.05% of the applied dose (representing a total amount permeated of 11.28+/-2.55 microg/cm2). The penetration of [14C]salicylic acid [applied at a concentration o...Continue Reading

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Citations

Apr 20, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Carmen Alvarez-Lorenzo, Angel Concheiro
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Aug 27, 2021·Archives of Toxicology·Enzo Zini Moreira SilvaDaniela Morais Leme

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