Percutaneous penetration via hand eczema is the major accelerating factor for systemic absorption of toluene and xylene during car spray painting

Contact Dermatitis
Ryosuke HinoYoshiki Tokura

Abstract

For absorption of organic solvents, the respiratory tract is well known as the major site, but percutaneous absorption might be critical in some workplaces. The aim of the study is to determine whether the skin, if disordered, is 1 of the major routes of organic solvent absorption. 72 male workers who painted the car body in the booth of a Japanese car company were participated in this study. The severity of hand eczema, urinary metabolites of organic solvents and the concentration of airborne organic solvents were measured. The correlation coefficiency between the skin severity index and the urinary concentration of hippuric acid or methylhippuric acid was statistically significant. There was no significant correlation between their urinary values and the air concentration of mixed organic solvents. The skin is a more critical absorption route for organic solvents than the respiratory tract in some occupational settings. Hand eczema is a common disease and has a possibility to be a critical absorption route of organic solvents.

References

Feb 1, 1986·The Journal of Investigative Dermatology·R C Scott, P H Dugard
Mar 1, 1980·Scandinavian Journal of Work, Environment & Health·K Husman
Jan 1, 1996·Current Problems in Dermatology·B Meding
Jan 1, 1996·Current Problems in Dermatology·U FunkeM Fartasch
Jun 20, 1997·The Science of the Total Environment·M OgataH Michitsuji
Aug 1, 1997·The Journal of Investigative Dermatology·T NishijimaM Takigawa
Apr 2, 1998·International Archives of Occupational and Environmental Health·P J Coenraads, T L Diepgen
Nov 24, 1998·International Archives of Occupational and Environmental Health·C H PierceD A Kalman
May 29, 2000·International Journal of Occupational and Environmental Health·A Boman, H I Maibach
May 27, 2003·The Annals of Occupational Hygiene·G A Jacobson, S McLean
May 28, 2003·International Archives of Occupational and Environmental Health·Peter-Jan Coenraads, Thomas L Diepgen

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Citations

Jan 13, 2015·Environmental Health Insights·Stacey E Anderson, B Jean Meade
Feb 25, 2009·International Archives of Occupational and Environmental Health·Sanja Kezic, J B Nielsen
Aug 24, 2012·Occupational Medicine·V H ArrandaleD L Holness
Feb 6, 2014·Risk Analysis : an Official Publication of the Society for Risk Analysis·Kenneth T Bogen, Patrick J Sheehan
Jul 28, 2011·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Horst Christoph BrodingThomas Brüning

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