Percutaneous permeation and skin irritation of JP-8+100 jet fuel in a porcine model

Toxicology Letters
N KanikkannanM Singh

Abstract

JP-8 is the major jet fuel used by US Air Force. JP-8+100 is a new jet fuel recently introduced by the US Air Force, which contains JP-8 plus three performance additives [butylated hydroxytoluene (BHT), metal deactivator (MDA) and 8Q405]. The purpose of the present study was to investigate the percutaneous permeation of JP-8+100 across pig ear skin in vitro and to study the effect of JP-8+100 exposure on the skin barrier function, moisture content and irritation in Yucatan minipigs. The influence of performance additives on the permeation of JP-8 was studied by adding each additive individually to JP-8. The percutaneous permeation and skin irritation data obtained with JP-8+100 were compared with that of JP-8. JP-8+100 spiked with 5.0 microCi of radiolabeled [14C]tridecane, nonane, naphthalene or toluene (selected components of JP-8+100) was used for the in vitro percutaneous permeation studies. For skin irritation studies, 250 microl of JP-8+100 was placed in a Hill top chamber and affixed over the marked treatment area for 24 h. The components of JP-8+100 such as tridecane, nonane, naphthalene and toluene permeated readily through pig ear skin without any apparent lag time. Compared to JP-8, the permeation of tridecane, tolue...Continue Reading

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Citations

Apr 20, 2004·Toxicology Letters·James N McDougal, James V Rogers
Jun 7, 2002·Toxicology·Narayanasamy KanikkannanMandip Singh
May 31, 2003·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Glenn RitchieDarryl Arfsten
Nov 25, 2003·Occupational and Environmental Medicine·P P EgeghyS M Rappaport
Oct 13, 2004·Toxicology and Applied Pharmacology·Luis A EspinozaMark E Smulson
Feb 25, 2006·Toxicology Letters·David KimLeena A Nylander-French
Apr 2, 2015·Toxicology Letters·Ivone JakasaPeter J Boogaard

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