Percutaneous prick test irritant threshold concentrations for eight allergens in healthy nonsedated dogs in the USA

Veterinary Dermatology
Matthew J H Carnett, Jon D Plant

Abstract

Percutaneous testing (PT) is preferred to intradermal testing in humans for the in vivo identification of allergen hypersensitivity, but the methodology has not been well described for use in dogs with atopic dermatitis. To identify the irritant threshold concentrations (ITC) of eight aeroallergens using a commercial prick test device in normal dogs. Twenty healthy, privately owned dogs. Percutaneous testing was performed using the GREER® Pick® System (Stallergenes Greer; Lenoir, NC, USA). Five dilutions of glycerinated extracts of Bromis inermis, Sorghum halepense, Chenopodium album, Ambrosia psilostachya, Salix nigra and Acer negundo, as well as four dilutions of Dermatophagoides farinae and D. pteronyssinus were included. Glycerinated histamine (6 mg/ml) and glycerin/Coca's solution were used for the positive and negative controls, respectively. Orthogonal wheal diameters were measured for each test site every 5 min for 25 min. Reactions were considered significant when the average wheal diameter was equal to or greater than the mean of the positive and negative controls. Significant reactions were noted in five of 20 (25%) of dogs. The ITC (≤10% of dogs reacting) were 1:20 w/v for B. inermis and S. nigra, 1:400 w/v for D. f...Continue Reading

References

Mar 21, 1998·The Journal of Allergy and Clinical Immunology·H S NelsonD McCormick
May 18, 1999·The Journal of Allergy and Clinical Immunology·R A WoodP A Eggleston
Sep 13, 2001·Veterinary Immunology and Immunopathology·A Hillier, D J DeBoer
Nov 5, 2011·Allergy·J BousquetUNKNOWN Allergic Rhinitis and its Impact on Asthma
Jul 6, 2013·Veterinary Dermatology·Michael A RossiRaweewan Hoontrakoon
Aug 16, 2015·BMC Veterinary Research·Thierry OlivryUNKNOWN International Committee on Allergic Diseases of Animals

❮ Previous
Next ❯

Citations

Jan 21, 2021·Veterinary Dermatology·Domenico SantoroHilary Jackson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.