Percutaneous pulmonary vein cryoablation to treat atrial fibrillation

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
Tom WongD Wyn Davies

Abstract

Cryothermic tissue injury, unlike hyperthermic tissue injury, preserves tissue architecture and causes less thrombus formation, and thus may prevent venous stenosis and stroke in ablating pulmonary veins (PVs) to treat patients with atrial fibrillation (AF). We investigate the feasibility, efficacy, safety and clinical outcome of using percutaneous cryoablation to treat such patients. Thirty-one patients who had drug refractory paroxysmal (20) or persistent (11) AF underwent 37 PV ablative procedures using a 4 mm- or 6 mm-tipped 7F cryoablation catheter (CryoCath Technologies Inc., Quebec, Canada). Segmental isolation at the veno-atrial junction was guided by a distal circumferential mapping catheter. A total of 47 PV were ablated, of which 35/47 (74%) were electrically isolated and the remaining 12/47 had attenuation of PV electrograms, altered activation sequence, and marked slowing of left atrial-PV conduction. There was no change in PV diameter, either immediately following cryoablation (21 +/- 5 versus 22 +/- 6, p = 0.69), or at 18 +/- 9 months follow-up (22 +/- 5 versus 22 +/- 5 mm, p = 0.23). There was no clinical thromboembolic event. The duration of cryoablation for each treated PV and procedural duration was 65 +/- 39...Continue Reading

Citations

May 23, 2006·European Radiology·Ruzica MaksimovićPetar M Seferović
Nov 26, 2009·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Marcus WieczorekAli Reza Salili
May 20, 2011·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Uwe DorwarthEllen Hoffmann
May 5, 2005·The Heart Surgery Forum·Gianluigi BisleriClaudio Muneretto
Aug 16, 2005·The Heart Surgery Forum·Gianluigi BisleriClaudio Muneretto
Jan 17, 2009·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Yves Van BelleLuc Jordaens
Dec 25, 2015·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Yi GangMark M Gallagher
Apr 15, 2005·Journal of Cardiovascular Electrophysiology·Thomas Arentz
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Apr 3, 2020·Journal of Cardiovascular Electrophysiology·Jason G Andrade

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