Percutaneous radiofrequency ablation for unresectable large hepatic tumours during hepatic blood flow occlusion in four patients

Clinical Radiology
N MiyamotoH Maguchi

Abstract

To evaluate percutaneous radiofrequency (RF) ablation therapy for unresectable large hepatic tumours combined with regional interruption of hepatic blood flow, and to assess the safety and efficacy of this procedure. Four patients with hepatic tumours were enrolled in this study. Patients were treated by a single session of RF ablation during occlusion of both hepatic artery and hepatic vein. Tumour size ranged from 45-57 mm (mean 50.2 mm). Initial therapeutic efficacy was evaluated with helical computed tomography (CT) performed within 9 days after the treatment. CT or magnetic resonance imaging (MRI) was performed every 2-3 months thereafter. The largest axis of coagulated lesions after the ablation was 50-60 mm (mean 56.5 mm) in diameter. The ablation therapy was considered complete in three patients; after a mean follow-up of 12.7 months, CT and MRI revealed complete destruction of their tumours. One patient required further treatment. No severe complications occurred. Although further studies are needed, in this limited clinical trial a local ablation area exceeding 50 mm in diameter was achieved safely.

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Citations

Sep 13, 2006·Cardiovascular and Interventional Radiology·Deepak SudheendraBradford J Wood
Apr 20, 2007·International Journal of Clinical Oncology·Toshiyuki Matsuoka, Tomohisa Okuma
Mar 1, 2006·Seminars in Interventional Radiology·Michael J Stone, Bradford J Wood
Jun 17, 2006·Journal of Vascular and Interventional Radiology : JVIR·Steven C RoseRalph B Vance
Aug 30, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G GarceaG J Maddern
Apr 3, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J-P RitzC Holmer
Mar 27, 2007·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·See-Ying ChiouLaurence Needleman

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